Saksela K - Search Results

1

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.

Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P. Aitio O, et al. Among authors: saksela k. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. doi: 10.1073/pnas.1010243107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098279 Free PMC article.

2

Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.

Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, Taskén K, Saksela K. Kesti T, et al. Among authors: saksela k. J Immunol. 2007 Jul 15;179(2):878-85. doi: 10.4049/jimmunol.179.2.878. J Immunol. 2007. PMID: 17617578

3

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, Saksela K. Heikkinen LS, et al. Among authors: saksela k. J Biol Chem. 2008 Feb 29;283(9):5719-27. doi: 10.1074/jbc.M707195200. Epub 2007 Dec 28. J Biol Chem. 2008. PMID: 18165234 Free article.

4

Structural basis of PxxDY motif recognition in SH3 binding.

Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, Tossavainen H, Saksela K, Permi P. Aitio O, et al. Among authors: saksela k. J Mol Biol. 2008 Sep 26;382(1):167-78. doi: 10.1016/j.jmb.2008.07.008. Epub 2008 Jul 11. J Mol Biol. 2008. PMID: 18644376

5

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation.

Vingadassalom D, Kazlauskas A, Skehan B, Cheng HC, Magoun L, Robbins D, Rosen MK, Saksela K, Leong JM. Vingadassalom D, et al. Among authors: saksela k. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6754-9. doi: 10.1073/pnas.0809131106. Epub 2009 Apr 6. Proc Natl Acad Sci U S A. 2009. PMID: 19366662 Free PMC article.

6

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Schmaier AA, et al. Among authors: saksela k. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21167-72. doi: 10.1073/pnas.0906436106. Epub 2009 Nov 25. Proc Natl Acad Sci U S A. 2009. PMID: 19940238 Free PMC article.

7

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication.

Neuvonen M, Kazlauskas A, Martikainen M, Hinkkanen A, Ahola T, Saksela K. Neuvonen M, et al. Among authors: saksela k. PLoS Pathog. 2011 Nov;7(11):e1002383. doi: 10.1371/journal.ppat.1002383. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22114558 Free PMC article.

8

SH3 domain ligand binding: What's the consensus and where's the specificity?

Saksela K, Permi P. Saksela K, et al. FEBS Lett. 2012 Aug 14;586(17):2609-14. doi: 10.1016/j.febslet.2012.04.042. Epub 2012 May 2. FEBS Lett. 2012. PMID: 22710157 Free article. Review.

9

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P. Aitio O, et al. Among authors: saksela k. Structure. 2012 Oct 10;20(10):1692-703. doi: 10.1016/j.str.2012.07.015. Epub 2012 Aug 23. Structure. 2012. PMID: 22921828 Free PMC article.

10

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M. Amako Y, et al. Among authors: saksela k. J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15. J Biol Chem. 2013. PMID: 23857585 Free PMC article.

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