Lessene G - Search Results

1

Benzoylureas as removable cis amide inducers: synthesis of cyclic amides via ring closing metathesis (RCM).

Brady RM, Khakham Y, Lessene G, Baell JB. Brady RM, et al. Among authors: lessene g. Org Biomol Chem. 2011 Feb 7;9(3):656-8. doi: 10.1039/c0ob00723d. Epub 2010 Nov 18. Org Biomol Chem. 2011. PMID: 21088766

2

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.

He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, Kawakami, Hsieh CY, Kung HJ, Lessene G, Baell J, Levitzki A, Maruta H. He H, et al. Among authors: lessene g. Cancer Biol Ther. 2004 Jan;3(1):96-101. doi: 10.4161/cbt.3.1.643. Epub 2004 Jan 29. Cancer Biol Ther. 2004. PMID: 14726663 Free article.

3

A concise total synthesis of naamidine A.

Aberle NS, Lessene G, Watson KG. Aberle NS, et al. Among authors: lessene g. Org Lett. 2006 Feb 2;8(3):419-21. doi: 10.1021/ol052568o. Org Lett. 2006. PMID: 16435849

4

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).

Hirokawa Y, Levitzki A, Lessene G, Baell J, Xiao Y, Zhu H, Maruta H. Hirokawa Y, et al. Among authors: lessene g. Cancer Lett. 2007 Jan 8;245(1-2):242-51. doi: 10.1016/j.canlet.2006.01.018. Epub 2006 Mar 15. Cancer Lett. 2007. PMID: 16540233

5

Effects of modulators of Ca(2+)-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo.

Ferens D, Baell J, Lessene G, Smith JE, Furness JB. Ferens D, et al. Among authors: lessene g. Neurogastroenterol Motil. 2007 May;19(5):383-9. doi: 10.1111/j.1365-2982.2007.00898.x. Neurogastroenterol Motil. 2007. PMID: 17509020

6

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange.

Lessene G, Smith BJ, Gable RW, Baell JB. Lessene G, et al. J Org Chem. 2009 Sep 4;74(17):6511-25. doi: 10.1021/jo900871a. J Org Chem. 2009. PMID: 19711992

7

Synthesis of azide-alkyne fragments for "click" chemical applications. Part 2. Formation of oligomers from orthogonally protected chiral trialkylsilylhomopropargyl azides and homopropargyl alcohols.

Montagnat OD, Lessene G, Hughes AB. Montagnat OD, et al. Among authors: lessene g. J Org Chem. 2010 Jan 15;75(2):390-8. doi: 10.1021/jo9021887. J Org Chem. 2010. PMID: 20000729

8

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.

Sleebs BE, Czabotar PE, Fairbrother WJ, Fairlie WD, Flygare JA, Huang DC, Kersten WJ, Koehler MF, Lessene G, Lowes K, Parisot JP, Smith BJ, Smith ML, Souers AJ, Street IP, Yang H, Baell JB. Sleebs BE, et al. Among authors: lessene g. J Med Chem. 2011 Mar 24;54(6):1914-26. doi: 10.1021/jm101596e. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366295

9

Synthesis of conformationally constrained benzoylureas as BH3-mimetics.

Brady RM, Hatzis E, Connor T, Street IP, Baell JB, Lessene G. Brady RM, et al. Among authors: lessene g. Org Biomol Chem. 2012 Jul 21;10(27):5230-7. doi: 10.1039/c2ob25618e. Epub 2012 May 30. Org Biomol Chem. 2012. PMID: 22648632

10

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG. Lessene G, et al. Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21. Nat Chem Biol. 2013. PMID: 23603658

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