Tan J - Search Results

1

B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.

Tan J, Lee PL, Li Z, Jiang X, Lim YC, Hooi SC, Yu Q. Tan J, et al. Cancer Cell. 2010 Nov 16;18(5):459-71. doi: 10.1016/j.ccr.2010.10.021. Cancer Cell. 2010. PMID: 21075311 Free article.

2

Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells.

Tan J, Zhuang L, Leong HS, Iyer NG, Liu ET, Yu Q. Tan J, et al. Cancer Res. 2005 Oct 1;65(19):9012-20. doi: 10.1158/0008-5472.CAN-05-1226. Cancer Res. 2005. PMID: 16204075

3

Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.

Zhao Y, Tan J, Zhuang L, Jiang X, Liu ET, Yu Q. Zhao Y, et al. Among authors: tan j. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16090-5. doi: 10.1073/pnas.0505585102. Epub 2005 Oct 21. Proc Natl Acad Sci U S A. 2005. PMID: 16243973 Free PMC article.

4

Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity.

Tan J, Zhuang L, Jiang X, Yang KK, Karuturi KM, Yu Q. Tan J, et al. J Biol Chem. 2006 Apr 14;281(15):10508-15. doi: 10.1074/jbc.M512719200. Epub 2006 Feb 13. J Biol Chem. 2006. PMID: 16476732 Free article.

5

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.

Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RK, Tan PB, Liu ET, Yu Q. Tan J, et al. Among authors: tan pb. Genes Dev. 2007 May 1;21(9):1050-63. doi: 10.1101/gad.1524107. Epub 2007 Apr 16. Genes Dev. 2007. PMID: 17437993 Free PMC article.

6

Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress.

Li J, Tan J, Zhuang L, Banerjee B, Yang X, Chau JF, Lee PL, Hande MP, Li B, Yu Q. Li J, et al. Among authors: tan j. Cancer Res. 2007 Dec 1;67(23):11317-26. doi: 10.1158/0008-5472.CAN-07-1088. Cancer Res. 2007. PMID: 18056458

7

DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.

Jiang X, Tan J, Li J, Kivimäe S, Yang X, Zhuang L, Lee PL, Chan MT, Stanton LW, Liu ET, Cheyette BN, Yu Q. Jiang X, et al. Among authors: tan j. Cancer Cell. 2008 Jun;13(6):529-41. doi: 10.1016/j.ccr.2008.04.019. Cancer Cell. 2008. PMID: 18538736 Free PMC article.

8

PDK1-driven Myc signaling regulates cellular response to mTOR inhibitors.

Tan J, Yu Q. Tan J, et al. Cell Cycle. 2011 Apr 1;10(7):1019-20. doi: 10.4161/cc.10.7.15163. Epub 2011 Apr 1. Cell Cycle. 2011. PMID: 21430441 No abstract available.

9

Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy.

Tan J, Yu Q. Tan J, et al. Chin J Cancer. 2013 Jul;32(7):376-9. doi: 10.5732/cjc.012.10287. Epub 2013 May 14. Chin J Cancer. 2013. PMID: 23668928 Free PMC article. Review.

10

PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy.

Tan J, Li Z, Lee PL, Guan P, Aau MY, Lee ST, Feng M, Lim CZ, Lee EY, Wee ZN, Lim YC, Karuturi RK, Yu Q. Tan J, et al. Cancer Discov. 2013 Oct;3(10):1156-71. doi: 10.1158/2159-8290.CD-12-0595. Epub 2013 Jul 25. Cancer Discov. 2013. PMID: 23887393

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