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Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses.
Janissen R, Woodman A, Shengjuler D, Vallet T, Lee KM, Kuijpers L, Moustafa IM, Fitzgerald F, Huang PN, Perkins AL, Harki DA, Arnold JJ, Solano B, Shih SR, Vignuzzi M, Cameron CE, Dekker NH. Janissen R, et al. Among authors: arnold jj. Mol Cell. 2021 Nov 4;81(21):4467-4480.e7. doi: 10.1016/j.molcel.2021.10.003. Epub 2021 Oct 22. Mol Cell. 2021. PMID: 34687604 Free PMC article.
RNA virus population diversity, an optimum for maximal fitness and virulence.
Korboukh VK, Lee CA, Acevedo A, Vignuzzi M, Xiao Y, Arnold JJ, Hemperly S, Graci JD, August A, Andino R, Cameron CE. Korboukh VK, et al. Among authors: arnold jj. J Biol Chem. 2014 Oct 24;289(43):29531-44. doi: 10.1074/jbc.M114.592303. Epub 2014 Sep 11. J Biol Chem. 2014. PMID: 25213864 Free PMC article.
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: arnold jj. PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25799064 Free PMC article.
Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase.
Gazina EV, Smidansky ED, Holien JK, Harrison DN, Cromer BA, Arnold JJ, Parker MW, Cameron CE, Petrou S. Gazina EV, et al. Among authors: arnold jj. J Virol. 2011 Oct;85(19):10364-74. doi: 10.1128/JVI.05022-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795353 Free PMC article.
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.
Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, Cho A, Perry J, Vela JE, Park Y, Xu Y, Tian Y, Babusis D, Barauskus O, Peterson BR, Gnatt A, Kashlev M, Zhong W, Cameron CE. Arnold JJ, et al. PLoS Pathog. 2012;8(11):e1003030. doi: 10.1371/journal.ppat.1003030. Epub 2012 Nov 15. PLoS Pathog. 2012. PMID: 23166498 Free PMC article.
210 results