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Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
Ghosh AK, Brindisi M, Yen YC, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Ghosh AK, et al. Among authors: huang x. Bioorg Med Chem Lett. 2015 Feb 1;25(3):668-72. doi: 10.1016/j.bmcl.2014.11.087. Epub 2014 Dec 6. Bioorg Med Chem Lett. 2015. PMID: 25537272 Free PMC article.
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies.
Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Ghosh AK, et al. Among authors: huang x. ChemMedChem. 2019 Mar 5;14(5):545-560. doi: 10.1002/cmdc.201800725. Epub 2019 Feb 5. ChemMedChem. 2019. PMID: 30637955 Free PMC article.
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