Chang WP - Search Results

1

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.

Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. Chang WP, et al. FASEB J. 2011 Feb;25(2):775-84. doi: 10.1096/fj.10-167213. Epub 2010 Nov 8. FASEB J. 2011. PMID: 21059748 Free PMC article.

2

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT 3rd, Chang W. Tang J, et al. J Mol Neurosci. 2003;20(3):299-304. doi: 10.1385/JMN:20:3:299. J Mol Neurosci. 2003. PMID: 14501012 Review.

3

Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications.

Hong L, He X, Huang X, Chang W, Tang J. Hong L, et al. Acta Biochim Biophys Sin (Shanghai). 2004 Dec;36(12):787-92. doi: 10.1093/abbs/36.12.787. Acta Biochim Biophys Sin (Shanghai). 2004. PMID: 15592644 Review.

4

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.

He X, Chang WP, Koelsch G, Tang J. He X, et al. Among authors: chang wp. FEBS Lett. 2002 Jul 31;524(1-3):183-7. doi: 10.1016/s0014-5793(02)03052-1. FEBS Lett. 2002. PMID: 12135764 Free article.

5

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.

Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J. Chang WP, et al. J Neurochem. 2004 Jun;89(6):1409-16. doi: 10.1111/j.1471-4159.2004.02452.x. J Neurochem. 2004. PMID: 15189343 Free article.

6

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.

Huang XP, Chang WP, Koelsch G, Turner RT 3rd, Lupu F, Tang J. Huang XP, et al. Among authors: chang wp. J Biol Chem. 2004 Sep 3;279(36):37886-94. doi: 10.1074/jbc.M402130200. Epub 2004 Jun 14. J Biol Chem. 2004. PMID: 15197182 Free article.

7

Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization.

Chang WP, Downs D, Huang XP, Da H, Fung KM, Tang J. Chang WP, et al. FASEB J. 2007 Oct;21(12):3184-96. doi: 10.1096/fj.06-7993com. Epub 2007 May 10. FASEB J. 2007. PMID: 17494994

8

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Ghosh AK, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1031-6. doi: 10.1016/j.bmcl.2007.12.028. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18180160 Free PMC article.

9

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

He X, Li F, Chang WP, Tang J. He X, et al. Among authors: chang wp. J Biol Chem. 2005 Mar 25;280(12):11696-703. doi: 10.1074/jbc.M411296200. Epub 2004 Dec 21. J Biol Chem. 2005. PMID: 15615712 Free article.

10

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. J Med Chem. 2007 May 17;50(10):2399-407. doi: 10.1021/jm061338s. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432843

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