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Affinity maturation of antibodies assisted by in silico modeling.
Barderas R, Desmet J, Timmerman P, Meloen R, Casal JI. Barderas R, et al. Among authors: desmet j. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9029-34. doi: 10.1073/pnas.0801221105. Epub 2008 Jun 23. Proc Natl Acad Sci U S A. 2008. PMID: 18574150 Free PMC article.
Affinity maturation by semi-rational approaches.
Barderas R, Desmet J, Alard P, Casal JI. Barderas R, et al. Among authors: desmet j. Methods Mol Biol. 2012;907:463-86. doi: 10.1007/978-1-61779-974-7_27. Methods Mol Biol. 2012. PMID: 22907369
Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke E, Van Trimpont M, Desmet J, Pieters T, Reunes L, Demoen L, Vuylsteke M, Loverix S, Vandenbroucke K, Alard P, Henderikx P, Deroo S, Baatz F, Lorent E, Thiolloy S, Somers K, McGrath Y, Van Vlierberghe P, Lasters I, Savvides SN. Pannecoucke E, et al. Among authors: desmet j. Sci Adv. 2021 Mar 26;7(13):eabe1682. doi: 10.1126/sciadv.abe1682. Print 2021 Mar. Sci Adv. 2021. PMID: 33771865 Free PMC article.
Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains.
Staelens S, Desmet J, Ngo TH, Vauterin S, Pareyn I, Barbeaux P, Van Rompaey I, Stassen JM, Deckmyn H, Vanhoorelbeke K. Staelens S, et al. Among authors: desmet j. Mol Immunol. 2006 Mar;43(8):1243-57. doi: 10.1016/j.molimm.2005.07.018. Epub 2005 Aug 22. Mol Immunol. 2006. PMID: 16118019
Structural basis of IL-23 antagonism by an Alphabody protein scaffold.
Desmet J, Verstraete K, Bloch Y, Lorent E, Wen Y, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides SN. Desmet J, et al. Nat Commun. 2014 Oct 30;5:5237. doi: 10.1038/ncomms6237. Nat Commun. 2014. PMID: 25354530 Free PMC article.
86 results