Pellecchia M - Search Results

1

Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Stebbins JL, Placzek W, Zhai D, Wu B, Rega MF, Zhang Z, Cellitti J, Yang L, Dahl R, Reed JC, Pellecchia M. Wei J, et al. Among authors: pellecchia m. J Med Chem. 2010 Nov 25;53(22):8000-11. doi: 10.1021/jm100746q. Epub 2010 Oct 29. J Med Chem. 2010. PMID: 21033669 Free PMC article.

2

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. Kitada S, et al. Among authors: pellecchia m. J Med Chem. 2003 Sep 25;46(20):4259-64. doi: 10.1021/jm030190z. J Med Chem. 2003. PMID: 13678404

3

Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.

Leone M, Zhai D, Sareth S, Kitada S, Reed JC, Pellecchia M. Leone M, et al. Among authors: pellecchia m. Cancer Res. 2003 Dec 1;63(23):8118-21. Cancer Res. 2003. PMID: 14678963

4

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

Becattini B, Kitada S, Leone M, Monosov E, Chandler S, Zhai D, Kipps TJ, Reed JC, Pellecchia M. Becattini B, et al. Among authors: pellecchia m. Chem Biol. 2004 Mar;11(3):389-95. doi: 10.1016/j.chembiol.2004.02.020. Chem Biol. 2004. PMID: 15123268

5

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy.

Pellecchia M, Reed JC. Pellecchia M, et al. Curr Pharm Des. 2004;10(12):1387-98. doi: 10.2174/1381612043384880. Curr Pharm Des. 2004. PMID: 15134489 Review.

6

Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.

Becattini B, Sareth S, Zhai D, Crowell KJ, Leone M, Reed JC, Pellecchia M. Becattini B, et al. Among authors: pellecchia m. Chem Biol. 2004 Aug;11(8):1107-17. doi: 10.1016/j.chembiol.2004.05.022. Chem Biol. 2004. PMID: 15324812

7

Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach.

Fattorusso R, Jung D, Crowell KJ, Forino M, Pellecchia M. Fattorusso R, et al. Among authors: pellecchia m. J Med Chem. 2005 Mar 10;48(5):1649-56. doi: 10.1021/jm0493212. J Med Chem. 2005. PMID: 15743206

8

Apoptosis-based therapies for hematologic malignancies.

Reed JC, Pellecchia M. Reed JC, et al. Among authors: pellecchia m. Blood. 2005 Jul 15;106(2):408-18. doi: 10.1182/blood-2004-07-2761. Epub 2005 Mar 29. Blood. 2005. PMID: 15797997 Free article. Review.

9

Virtual docking approaches to protein kinase B inhibition.

Forino M, Jung D, Easton JB, Houghton PJ, Pellecchia M. Forino M, et al. Among authors: pellecchia m. J Med Chem. 2005 Apr 7;48(7):2278-81. doi: 10.1021/jm048962u. J Med Chem. 2005. PMID: 15801821

10

Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.

Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S. Santelli E, et al. Among authors: pellecchia m. J Biol Chem. 2005 Oct 7;280(40):34278-87. doi: 10.1074/jbc.M506707200. Epub 2005 Aug 4. J Biol Chem. 2005. PMID: 16085652 Free article.

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