C-Gaudreault R - Search Results

1

Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.

Fortin S, Bouchon B, Chambon C, Lacroix J, Moreau E, Chezal JM, Degoul F, C-Gaudreault R. Fortin S, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):460-7. doi: 10.1124/jpet.110.171082. Epub 2010 Oct 26. J Pharmacol Exp Ther. 2011. PMID: 20978170

2

Antimitotic antitumor agents: synthesis, structure-activity relationships, and biological characterization of N-aryl-N'-(2-chloroethyl)ureas as new selective alkylating agents.

Mounetou E, Legault J, Lacroix J, C-Gaudreault R. Mounetou E, et al. J Med Chem. 2001 Mar 1;44(5):694-702. doi: 10.1021/jm0010264. J Med Chem. 2001. PMID: 11262080

3

A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.

Mounetou E, Legault J, Lacroix J, C -Gaudreault R. Mounetou E, et al. J Med Chem. 2003 Nov 6;46(23):5055-63. doi: 10.1021/jm030908a. J Med Chem. 2003. PMID: 14584955

4

Massive cell vacuolization induced by organic amines such as procainamide.

Morissette G, Moreau E, C-Gaudreault R, Marceau F. Morissette G, et al. J Pharmacol Exp Ther. 2004 Jul;310(1):395-406. doi: 10.1124/jpet.104.066084. Epub 2004 Mar 8. J Pharmacol Exp Ther. 2004. PMID: 15007104

5

Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.

Petitclerc E, Deschesnes RG, Côté MF, Marquis C, Janvier R, Lacroix J, Miot-Noirault E, Legault J, Mounetou E, Madelmont JC, C -Gaudreault R. Petitclerc E, et al. Cancer Res. 2004 Jul 1;64(13):4654-63. doi: 10.1158/0008-5472.CAN-03-3715. Cancer Res. 2004. PMID: 15231678

6

Optimized N-phenyl-N'-(2-chloroethyl)ureas as potential antineoplastic agents: synthesis and growth inhibition activity.

Moreau E, Fortin S, Desjardins M, Rousseau JL, Petitclerc E, C-Gaudreault R. Moreau E, et al. Bioorg Med Chem. 2005 Dec 15;13(24):6703-12. doi: 10.1016/j.bmc.2005.07.048. Epub 2005 Sep 13. Bioorg Med Chem. 2005. PMID: 16165366 Free article.

7

N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping.

Morissette G, Moreau E, C-Gaudreault R, Marceau F. Morissette G, et al. Mol Pharmacol. 2005 Dec;68(6):1576-89. doi: 10.1124/mol.105.016527. Epub 2005 Sep 23. Mol Pharmacol. 2005. PMID: 16183854

8

Microtubule-destabilizing agents induce focal adhesion structure disorganization and anoikis in cancer cells.

Deschesnes RG, Patenaude A, Rousseau JL, Fortin JS, Ricard C, Côté MF, Huot J, C-Gaudreault R, Petitclerc E. Deschesnes RG, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):853-64. doi: 10.1124/jpet.106.110957. Epub 2006 Nov 10. J Pharmacol Exp Ther. 2007. PMID: 17099073

9

N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.

Fortin S, Moreau E, Patenaude A, Desjardins M, Lacroix J, Rousseau JL, C-Gaudreault R. Fortin S, et al. Bioorg Med Chem. 2007 Feb 1;15(3):1430-8. doi: 10.1016/j.bmc.2006.11.005. Epub 2006 Nov 10. Bioorg Med Chem. 2007. PMID: 17118664 Free article.

10

N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

Fortin S, Moreau E, Lacroix J, Teulade JC, Patenaude A, C-Gaudreault R. Fortin S, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2000-4. doi: 10.1016/j.bmcl.2007.01.023. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17291753 Free article.

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