Yu Z - Search Results

1

Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor.

He R, Yu Z, He Y, Zeng LF, Xu J, Wu L, Gunawan AM, Wang L, Jiang ZX, Zhang ZY. He R, et al. Among authors: yu z. ChemMedChem. 2010 Dec 3;5(12):2051-6. doi: 10.1002/cmdc.201000348. ChemMedChem. 2010. PMID: 20957718 Free PMC article.

2

Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.

He Y, Zeng LF, Yu ZH, He R, Liu S, Zhang ZY. He Y, et al. Bioorg Med Chem. 2012 Mar 15;20(6):1940-6. doi: 10.1016/j.bmc.2011.11.004. Epub 2011 Nov 9. Bioorg Med Chem. 2012. PMID: 22133902 Free PMC article.

3

A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.

Zhang S, Liu S, Tao R, Wei D, Chen L, Shen W, Yu ZH, Wang L, Jones DR, Dong XC, Zhang ZY. Zhang S, et al. J Am Chem Soc. 2012 Oct 31;134(43):18116-24. doi: 10.1021/ja308212y. Epub 2012 Oct 17. J Am Chem Soc. 2012. PMID: 23075115 Free PMC article.

4

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

He Y, Xu J, Yu ZH, Gunawan AM, Wu L, Wang L, Zhang ZY. He Y, et al. J Med Chem. 2013 Feb 14;56(3):832-42. doi: 10.1021/jm301781p. Epub 2013 Jan 25. J Med Chem. 2013. PMID: 23305444 Free PMC article.

5

Protein tyrosine phosphatases as potential therapeutic targets.

He RJ, Yu ZH, Zhang RY, Zhang ZY. He RJ, et al. Acta Pharmacol Sin. 2014 Oct;35(10):1227-46. doi: 10.1038/aps.2014.80. Epub 2014 Sep 15. Acta Pharmacol Sin. 2014. PMID: 25220640 Free PMC article. Review.

6

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY. He Y, et al. Bioorg Med Chem. 2015 Jun 15;23(12):2798-809. doi: 10.1016/j.bmc.2015.03.066. Epub 2015 Mar 31. Bioorg Med Chem. 2015. PMID: 25907364 Free PMC article.

7

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.

He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Zhang ZY. He R, et al. ACS Med Chem Lett. 2015 Nov 3;6(12):1231-5. doi: 10.1021/acsmedchemlett.5b00373. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713110 Free PMC article.

8

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Zhang X, et al. Among authors: yu z. J Med Chem. 2010 Mar 25;53(6):2482-93. doi: 10.1021/jm901645u. J Med Chem. 2010. PMID: 20170098 Free PMC article.

9

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.

Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY. Yu ZH, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4238-42. doi: 10.1016/j.bmcl.2011.05.078. Epub 2011 May 30. Bioorg Med Chem Lett. 2011. PMID: 21669525 Free PMC article.

10

Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations.

Yu ZH, Xu J, Walls CD, Chen L, Zhang S, Zhang R, Wu L, Wang L, Liu S, Zhang ZY. Yu ZH, et al. J Biol Chem. 2013 Apr 12;288(15):10472-82. doi: 10.1074/jbc.M113.450023. Epub 2013 Mar 1. J Biol Chem. 2013. PMID: 23457302 Free PMC article.

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