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EU framework 6 project: predictive toxicology (PredTox)--overview and outcome.
Suter L, Schroeder S, Meyer K, Gautier JC, Amberg A, Wendt M, Gmuender H, Mally A, Boitier E, Ellinger-Ziegelbauer H, Matheis K, Pfannkuch F. Suter L, et al. Among authors: gmuender h. Toxicol Appl Pharmacol. 2011 Apr 15;252(2):73-84. doi: 10.1016/j.taap.2010.10.008. Epub 2010 Oct 16. Toxicol Appl Pharmacol. 2011. PMID: 20955723
The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury.
Ellinger-Ziegelbauer H, Adler M, Amberg A, Brandenburg A, Callanan JJ, Connor S, Fountoulakis M, Gmuender H, Gruhler A, Hewitt P, Hodson M, Matheis KA, McCarthy D, Raschke M, Riefke B, Schmitt CS, Sieber M, Sposny A, Suter L, Sweatman B, Mally A. Ellinger-Ziegelbauer H, et al. Among authors: gmuender h. Toxicol Appl Pharmacol. 2011 Apr 15;252(2):97-111. doi: 10.1016/j.taap.2010.09.022. Epub 2010 Oct 1. Toxicol Appl Pharmacol. 2011. PMID: 20888850
Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers.
Matheis KA, Com E, Gautier JC, Guerreiro N, Brandenburg A, Gmuender H, Sposny A, Hewitt P, Amberg A, Boernsen O, Riefke B, Hoffmann D, Mally A, Kalkuhl A, Suter L, Dieterle F, Staedtler F. Matheis KA, et al. Among authors: gmuender h. Toxicol Appl Pharmacol. 2011 Apr 15;252(2):112-22. doi: 10.1016/j.taap.2010.11.006. Epub 2010 Nov 21. Toxicol Appl Pharmacol. 2011. PMID: 21081137
A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat.
Boitier E, Amberg A, Barbié V, Blichenberg A, Brandenburg A, Gmuender H, Gruhler A, McCarthy D, Meyer K, Riefke B, Raschke M, Schoonen W, Sieber M, Suter L, Thomas CE, Sajot N. Boitier E, et al. Among authors: gmuender h. Toxicol Appl Pharmacol. 2011 Apr 15;252(2):85-96. doi: 10.1016/j.taap.2011.01.021. Epub 2011 Feb 26. Toxicol Appl Pharmacol. 2011. PMID: 21315101
The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.
Vinken M, Doktorova T, Ellinger-Ziegelbauer H, Ahr HJ, Lock E, Carmichael P, Roggen E, van Delft J, Kleinjans J, Castell J, Bort R, Donato T, Ryan M, Corvi R, Keun H, Ebbels T, Athersuch T, Sansone SA, Rocca-Serra P, Stierum R, Jennings P, Pfaller W, Gmuender H, Vanhaecke T, Rogiers V. Vinken M, et al. Among authors: gmuender h. Mutat Res. 2008 Sep-Oct;659(3):202-10. doi: 10.1016/j.mrrev.2008.04.006. Epub 2008 Apr 26. Mutat Res. 2008. PMID: 18514569 Review.
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J. Kuepfer L, et al. Among authors: gmuender h. Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. Arch Toxicol. 2018. PMID: 28852801 Free PMC article. No abstract available.
A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
Baier V, Clayton O, Nudischer R, Cordes H, Schneider ARP, Thiel C, Wittenberger T, Moritz W, Blank LM, Neumann UP, Trautwein C, Kelm J, Schrooders Y, Caiment F, Gmuender H, Roth A, Castell JV, Kleinjans J, Kuepfer L. Baier V, et al. Among authors: gmuender h. Clin Pharmacol Ther. 2021 Nov;110(5):1293-1301. doi: 10.1002/cpt.2406. Epub 2021 Sep 28. Clin Pharmacol Ther. 2021. PMID: 34462909
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.
Verheijen M, Schrooders Y, Gmuender H, Nudischer R, Clayton O, Hynes J, Niederer S, Cordes H, Kuepfer L, Kleinjans J, Caiment F. Verheijen M, et al. Among authors: gmuender h. Toxicol Lett. 2018 Sep 15;294:184-192. doi: 10.1016/j.toxlet.2018.05.029. Epub 2018 May 24. Toxicol Lett. 2018. PMID: 29803840 Free article.
42 results