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Targeting transcription factor activity as a strategy to inhibit pro-inflammatory genes involved in cystic fibrosis: decoy oligonucleotides and low-molecular weight compounds.
Cabrini G, Bezzerri V, Mancini I, Nicolis E, Dechecchi MC, Tamanini A, Lampronti I, Piccagli L, Bianchi N, Borgatti M, Gambari R. Cabrini G, et al. Among authors: nicolis e. Curr Med Chem. 2010;17(35):4392-404. doi: 10.2174/092986710793361243. Curr Med Chem. 2010. PMID: 20939807 Review.
Decoy oligodeoxyribonucleotides and peptide nucleic acids-DNA chimeras targeting nuclear factor kappa-B: inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa.
Gambari R, Borgatti M, Bezzerri V, Nicolis E, Lampronti I, Dechecchi MC, Mancini I, Tamanini A, Cabrini G. Gambari R, et al. Among authors: nicolis e. Biochem Pharmacol. 2010 Dec 15;80(12):1887-94. doi: 10.1016/j.bcp.2010.06.047. Epub 2010 Jul 6. Biochem Pharmacol. 2010. PMID: 20615393 Review.
Virtual screening against nuclear factor κB (NF-κB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-κB dependent biological functions involved in cystic fibrosis.
Piccagli L, Borgatti M, Nicolis E, Bianchi N, Mancini I, Lampronti I, Vevaldi D, Dall'Acqua F, Cabrini G, Gambari R. Piccagli L, et al. Among authors: nicolis e. Bioorg Med Chem. 2010 Dec 1;18(23):8341-9. doi: 10.1016/j.bmc.2010.09.063. Epub 2010 Oct 1. Bioorg Med Chem. 2010. PMID: 20980154
Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function.
Tamanini A, Borgatti M, Finotti A, Piccagli L, Bezzerri V, Favia M, Guerra L, Lampronti I, Bianchi N, Dall'Acqua F, Vedaldi D, Salvador A, Fabbri E, Mancini I, Nicolis E, Casavola V, Cabrini G, Gambari R. Tamanini A, et al. Among authors: nicolis e. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L380-90. doi: 10.1152/ajplung.00129.2010. Epub 2010 Dec 10. Am J Physiol Lung Cell Mol Physiol. 2011. PMID: 21148790 Free article.
We previously found that 5-methoxypsoralen reduces Pseudomonas aeruginosa-dependent IL-8 transcription in bronchial epithelial cell lines, with an IC(50) of 10 muM (Nicolis E, Lampronti I, Dechecchi MC, Borgatti M, Tamanini A, Bezzerri V, Bianchi N, Mazzon M, Mancin …
We previously found that 5-methoxypsoralen reduces Pseudomonas aeruginosa-dependent IL-8 transcription in bronchial epithelial cell lines, w …
Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3-1 cells: recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene.
Finotti A, Borgatti M, Bezzerri V, Nicolis E, Lampronti I, Dechecchi M, Mancini I, Cabrini G, Saviano M, Avitabile C, Romanelli A, Gambari R. Finotti A, et al. Among authors: nicolis e. Artif DNA PNA XNA. 2012 Apr-Jun;3(2):97-296. doi: 10.4161/adna.21061. Epub 2012 Apr 1. Artif DNA PNA XNA. 2012. PMID: 22772035 Free PMC article.
Anti-inflammatory effect of miglustat in bronchial epithelial cells.
Dechecchi MC, Nicolis E, Norez C, Bezzerri V, Borgatti M, Mancini I, Rizzotti P, Ribeiro CM, Gambari R, Becq F, Cabrini G. Dechecchi MC, et al. Among authors: nicolis e. J Cyst Fibros. 2008 Nov;7(6):555-65. doi: 10.1016/j.jcf.2008.06.002. Epub 2008 Sep 23. J Cyst Fibros. 2008. PMID: 18815075 Free article.
Am J Physiol Lung Cell Mol Physiol 2007; 292:L383-L395.] recently demonstrated that the inhibition of function of w/t CFTR produces an inflammatory profile that resembles that observed in CF patients, whereas we found that correction of F508del-CFTR function with MPB-07 down-modu …
Am J Physiol Lung Cell Mol Physiol 2007; 292:L383-L395.] recently demonstrated that the inhibition of function of w/t CFTR produces an infla …
83 results