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Oral administration of drugs with hypersensitivity potential induces germinal center hyperplasia in secondary lymphoid organ/tissue in Brown Norway rats, and this histological lesion is a promising candidate as a predictive biomarker for drug hypersensitivity occurrence in humans.
Tamura A, Miyawaki I, Yamada T, Kimura J, Funabashi H. Tamura A, et al. Among authors: yamada t. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):30-40. doi: 10.1016/j.taap.2013.04.022. Epub 2013 May 5. Toxicol Appl Pharmacol. 2013. PMID: 23651737
Optimal dose selection of N-methyl-N-nitrosourea for the rat comet assay to evaluate DNA damage in organs with different susceptibility to cytotoxicity.
Kitamoto S, Matsuyama R, Uematsu Y, Ogata K, Ota M, Yamada T, Miyata K, Funabashi H, Saito K. Kitamoto S, et al. Among authors: yamada t. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:129-36. doi: 10.1016/j.mrgentox.2015.05.001. Epub 2015 May 8. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 26212303
Genotoxicity evaluation of benzene, di(2-ethylhexyl) phthalate, and trisodium ethylenediamine tetraacetic acid monohydrate using a combined rat comet/micronucleus assays.
Kitamoto S, Matsuyama R, Uematsu Y, Ogata K, Ota M, Yamada T, Miyata K, Kimura J, Funabashi H, Saito K. Kitamoto S, et al. Among authors: yamada t. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:137-43. doi: 10.1016/j.mrgentox.2015.05.002. Epub 2015 May 8. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 26212304
Glomerulonephritis in a ferret with feline coronavirus infection.
Fujii Y, Tochitani T, Kouchi M, Matsumoto I, Yamada T, Funabashi H. Fujii Y, et al. Among authors: yamada t. J Vet Diagn Invest. 2015 Sep;27(5):637-40. doi: 10.1177/1040638715599570. Epub 2015 Aug 28. J Vet Diagn Invest. 2015. PMID: 26319601
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