Khosla C - Search Results

1

Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase.

Valenzano CR, You YO, Garg A, Keatinge-Clay A, Khosla C, Cane DE. Valenzano CR, et al. Among authors: khosla c. J Am Chem Soc. 2010 Oct 27;132(42):14697-9. doi: 10.1021/ja107344h. J Am Chem Soc. 2010. PMID: 20925342 Free PMC article.

2

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.

Pieper R, Luo G, Cane DE, Khosla C. Pieper R, et al. Among authors: khosla c. Nature. 1995 Nov 16;378(6554):263-6. doi: 10.1038/378263a0. Nature. 1995. PMID: 7477343

3

Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host.

Cane DE, Luo G, Khosla C, Kao CM, Katz L. Cane DE, et al. Among authors: khosla c. J Antibiot (Tokyo). 1995 Jul;48(7):647-51. doi: 10.7164/antibiotics.48.647. J Antibiot (Tokyo). 1995. PMID: 7649863 Free article.

4

Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.

Pieper R, Ebert-Khosla S, Cane D, Khosla C. Pieper R, et al. Among authors: khosla c. Biochemistry. 1996 Feb 20;35(7):2054-60. doi: 10.1021/bi952860b. Biochemistry. 1996. PMID: 8652546

5

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.

Kao CM, Pieper R, Cane DE, Khosla C. Kao CM, et al. Among authors: khosla c. Biochemistry. 1996 Sep 24;35(38):12363-8. doi: 10.1021/bi9616312. Biochemistry. 1996. PMID: 8823171

6

Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase.

Luo G, Pieper R, Rosa A, Khosla C, Cane DE. Luo G, et al. Among authors: khosla c. Bioorg Med Chem. 1996 Jul;4(7):995-9. doi: 10.1016/0968-0896(96)00096-x. Bioorg Med Chem. 1996. PMID: 8831969

7

A functional chimeric modular polyketide synthase generated via domain replacement.

Bedford D, Jacobsen JR, Luo G, Cane DE, Khosla C. Bedford D, et al. Among authors: khosla c. Chem Biol. 1996 Oct;3(10):827-31. doi: 10.1016/s1074-5521(96)90068-x. Chem Biol. 1996. PMID: 8939701

8

6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.

Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE. Tsukamoto N, et al. Among authors: khosla c. Biochemistry. 1996 Dec 3;35(48):15244-8. doi: 10.1021/bi961972f. Biochemistry. 1996. PMID: 8952473

9

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.

Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C. Pieper R, et al. Among authors: khosla c. Biochemistry. 1997 Feb 18;36(7):1846-51. doi: 10.1021/bi962324z. Biochemistry. 1997. PMID: 9048569

10

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.

Jacobsen JR, Hutchinson CR, Cane DE, Khosla C. Jacobsen JR, et al. Among authors: khosla c. Science. 1997 Jul 18;277(5324):367-9. doi: 10.1126/science.277.5324.367. Science. 1997. PMID: 9219693

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