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sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration.
Martin-Manso G, Calzada MJ, Chuman Y, Sipes JM, Xavier CP, Wolf V, Kuznetsova SA, Rubin JS, Roberts DD. Martin-Manso G, et al. Arch Biochem Biophys. 2011 May 15;509(2):147-56. doi: 10.1016/j.abb.2011.03.004. Epub 2011 Mar 21. Arch Biochem Biophys. 2011. PMID: 21402050 Free PMC article.