Loenarz C - Search Results

1

Structural studies on human 2-oxoglutarate dependent oxygenases.

McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. McDonough MA, et al. Among authors: loenarz c. Curr Opin Struct Biol. 2010 Dec;20(6):659-72. doi: 10.1016/j.sbi.2010.08.006. Epub 2010 Sep 29. Curr Opin Struct Biol. 2010. PMID: 20888218 Review.

2

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Flashman E, et al. Among authors: loenarz c. J Biol Chem. 2008 Feb 15;283(7):3808-15. doi: 10.1074/jbc.M707411200. Epub 2007 Dec 5. J Biol Chem. 2008. PMID: 18063574 Free article.

3

Expanding chemical biology of 2-oxoglutarate oxygenases.

Loenarz C, Schofield CJ. Loenarz C, et al. Nat Chem Biol. 2008 Mar;4(3):152-6. doi: 10.1038/nchembio0308-152. Nat Chem Biol. 2008. PMID: 18277970

4

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.

Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Pollard PJ, et al. Among authors: loenarz c. Biochem J. 2008 Dec 15;416(3):387-94. doi: 10.1042/BJ20081238. Biochem J. 2008. PMID: 18713068

5

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.

Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ. Lienard BM, et al. Among authors: loenarz c. Chem Commun (Camb). 2008 Dec 21;(47):6393-5. doi: 10.1039/b814440k. Epub 2008 Nov 5. Chem Commun (Camb). 2008. PMID: 19048166

6

Evidence for a stereoelectronic effect in human oxygen sensing.

Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Loenarz C, et al. Angew Chem Int Ed Engl. 2009;48(10):1784-7. doi: 10.1002/anie.200805427. Angew Chem Int Ed Engl. 2009. PMID: 19180614

7

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Stubbs CJ, et al. Among authors: loenarz c. J Med Chem. 2009 May 14;52(9):2799-805. doi: 10.1021/jm900285r. J Med Chem. 2009. PMID: 19364117

8

Oxygenase catalyzed 5-methylcytosine hydroxylation.

Loenarz C, Schofield CJ. Loenarz C, et al. Chem Biol. 2009 Jun 26;16(6):580-3. doi: 10.1016/j.chembiol.2009.06.002. Chem Biol. 2009. PMID: 19549596

9

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Chowdhury R, et al. Among authors: loenarz c. Structure. 2009 Jul 15;17(7):981-9. doi: 10.1016/j.str.2009.06.002. Structure. 2009. PMID: 19604478 Free article.

10

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. Mecinović J, et al. Among authors: loenarz c. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. doi: 10.1016/j.bmcl.2009.09.005. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19775891

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