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Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.
Mrkonjic M, Roslin NM, Greenwood CM, Raptis S, Pollett A, Laird PW, Pethe VV, Chiang T, Daftary D, Dicks E, Thibodeau SN, Gallinger S, Parfrey PS, Younghusband HB, Potter JD, Hudson TJ, McLaughlin JR, Green RC, Zanke BW, Newcomb PA, Paterson AD, Bapat B. Mrkonjic M, et al. Among authors: bapat b. PLoS One. 2010 Oct 13;5(10):e13314. doi: 10.1371/journal.pone.0013314. PLoS One. 2010. PMID: 20967208 Free PMC article.
Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries.
Ryan P, Mulligan AM, Aronson M, Ferguson SE, Bapat B, Semotiuk K, Holter S, Kwon J, Kalloger SE, Gilks CB, Gallinger S, Pollett A, Clarke BA. Ryan P, et al. Among authors: bapat b. Cancer. 2012 Feb 1;118(3):681-8. doi: 10.1002/cncr.26323. Epub 2011 Jun 30. Cancer. 2012. PMID: 21721000 Free article.
Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer.
Skeldon SC, Semotiuk K, Aronson M, Holter S, Gallinger S, Pollett A, Kuk C, van Rhijn B, Bostrom P, Cohen Z, Fleshner NE, Jewett MA, Hanna S, Shariat SF, Van Der Kwast TH, Evans A, Catto J, Bapat B, Zlotta AR. Skeldon SC, et al. Among authors: bapat b. Eur Urol. 2013 Feb;63(2):379-85. doi: 10.1016/j.eururo.2012.07.047. Epub 2012 Aug 2. Eur Urol. 2013. PMID: 22883484
Hereditary nonpolyposis colorectal cancer--molecular basis.
Brezden-Masley C, Aronson MD, Bapat B, Pollett A, Gryfe R, Redston M, Gallinger S. Brezden-Masley C, et al. Among authors: bapat b. Surgery. 2003 Jul;134(1):29-33. doi: 10.1067/msy.2003.176. Surgery. 2003. PMID: 12874579 Review. No abstract available.
204 results