Pflum MK - Search Results

1

A histone deacetylase-dependent screen in yeast.

Weerasinghe SV, Wambua M, Pflum MK. Weerasinghe SV, et al. Among authors: pflum mk. Bioorg Med Chem. 2010 Nov 1;18(21):7586-92. doi: 10.1016/j.bmc.2010.08.045. Epub 2010 Sep 20. Bioorg Med Chem. 2010. PMID: 20863708 Free PMC article.

2

Limited proteolysis of human histone deacetylase 1.

Kamath N, Karwowska-Desaulniers P, Pflum MK. Kamath N, et al. Among authors: pflum mk. BMC Biochem. 2006 Oct 5;7:22. doi: 10.1186/1471-2091-7-22. BMC Biochem. 2006. PMID: 17022812 Free PMC article.

3

Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.

Bieliauskas AV, Weerasinghe SV, Pflum MK. Bieliauskas AV, et al. Among authors: pflum mk. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2216-9. doi: 10.1016/j.bmcl.2007.01.117. Epub 2007 Feb 8. Bioorg Med Chem Lett. 2007. PMID: 17307359 Free PMC article.

4

Histone deacetylase 1 phosphorylation at S421 and S423 is constitutive in vivo, but dispensable in vitro.

Karwowska-Desaulniers P, Ketko A, Kamath N, Pflum MK. Karwowska-Desaulniers P, et al. Among authors: pflum mk. Biochem Biophys Res Commun. 2007 Sep 21;361(2):349-55. doi: 10.1016/j.bbrc.2007.06.167. Epub 2007 Jul 16. Biochem Biophys Res Commun. 2007. PMID: 17643391

5

Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold.

Singh EK, Ravula S, Pan CM, Pan PS, Vasko RC, Lapera SA, Weerasinghe SV, Pflum MK, McAlpine SR. Singh EK, et al. Among authors: pflum mk. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2549-54. doi: 10.1016/j.bmcl.2008.03.047. Epub 2008 Mar 20. Bioorg Med Chem Lett. 2008. PMID: 18381239 Free PMC article.

6

Isoform-selective histone deacetylase inhibitors.

Bieliauskas AV, Pflum MK. Bieliauskas AV, et al. Among authors: pflum mk. Chem Soc Rev. 2008 Jul;37(7):1402-13. doi: 10.1039/b703830p. Epub 2008 May 8. Chem Soc Rev. 2008. PMID: 18568166 Free PMC article. Review.

7

Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.

Weerasinghe SV, Estiu G, Wiest O, Pflum MK. Weerasinghe SV, et al. Among authors: pflum mk. J Med Chem. 2008 Sep 25;51(18):5542-51. doi: 10.1021/jm800081j. Epub 2008 Aug 27. J Med Chem. 2008. PMID: 18729444 Free PMC article.

8

The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.

Choi SE, Weerasinghe SV, Pflum MK. Choi SE, et al. Among authors: pflum mk. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6139-42. doi: 10.1016/j.bmcl.2011.08.027. Epub 2011 Aug 12. Bioorg Med Chem Lett. 2011. PMID: 21889343 Free PMC article.

9

The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.

Choi SE, Pflum MK. Choi SE, et al. Among authors: pflum mk. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7084-6. doi: 10.1016/j.bmcl.2012.09.093. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23089527 Free PMC article.

10

Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.

Wambua MK, Nalawansha DA, Negmeldin AT, Pflum MK. Wambua MK, et al. Among authors: pflum mk. J Med Chem. 2014 Feb 13;57(3):642-50. doi: 10.1021/jm401837e. Epub 2014 Jan 27. J Med Chem. 2014. PMID: 24405391 Free PMC article.

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