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Page 1
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.
Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Chen YT, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18585034 Free PMC article.
Mining a cathepsin inhibitor library for new antiparasitic drug leads.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.
The Trypanosoma cruzi protease cruzain mediates immune evasion.
Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. Among authors: mckerrow jh. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. Calvet CM, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006132. doi: 10.1371/journal.pntd.0006132. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29281643 Free PMC article.
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423
Proteomic analysis of skin invasion by blood fluke larvae.
Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. Hansell E, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2008 Jul 16;2(7):e262. doi: 10.1371/journal.pntd.0000262. PLoS Negl Trop Dis. 2008. PMID: 18629379 Free PMC article.
SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni.
Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. Dvorák J, et al. Among authors: mckerrow wh, mckerrow jh. PLoS Negl Trop Dis. 2009 Jun 2;3(6):e449. doi: 10.1371/journal.pntd.0000449. PLoS Negl Trop Dis. 2009. PMID: 19488406 Free PMC article.
352 results