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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.
Correia SS, Liu G, Jacobson S, Bernier SG, Tobin JV, Schwartzkopf CD, Atwater E, Lonie E, Rivers S, Carvalho A, Germano P, Tang K, Iyengar RR, Currie MG, Hadcock JR, Winrow CJ, Jones JE. Correia SS, et al. Among authors: lonie e. J Neuroinflammation. 2021 Sep 18;18(1):213. doi: 10.1186/s12974-021-02275-z. J Neuroinflammation. 2021. PMID: 34537066 Free PMC article.
The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.
Correia SS, Iyengar RR, Germano P, Tang K, Bernier SG, Schwartzkopf CD, Tobin J, Lee TW, Liu G, Jacobson S, Carvalho A, Rennie GR, Jung J, Renhowe PA, Lonie E, Winrow CJ, Hadcock JR, Jones JE, Currie MG. Correia SS, et al. Among authors: lonie e. Front Pharmacol. 2021 May 24;12:656561. doi: 10.3389/fphar.2021.656561. eCollection 2021. Front Pharmacol. 2021. PMID: 34108877 Free PMC article.
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells.
Liu G, Shea CM, Jones JE, Price GM, Warren W, Lonie E, Yan S, Currie MG, Profy AT, Masferrer JL, Zimmer DP. Liu G, et al. Among authors: lonie e. Am J Physiol Renal Physiol. 2020 Oct 1;319(4):F697-F711. doi: 10.1152/ajprenal.00003.2020. Epub 2020 Aug 31. Am J Physiol Renal Physiol. 2020. PMID: 32865013 Free article.