Hara A - Search Results

1

Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.

El-Kabbani O, Scammells PJ, Day T, Dhagat U, Endo S, Matsunaga T, Soda M, Hara A. El-Kabbani O, et al. Among authors: hara a. Eur J Med Chem. 2010 Nov;45(11):5309-17. doi: 10.1016/j.ejmech.2010.08.052. Epub 2010 Sep 17. Eur J Med Chem. 2010. PMID: 20850205

2

Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme.

Carbone V, Darmanin C, Ishikura S, Hara A, El-Kabbani O. Carbone V, et al. Among authors: hara a. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1469-74. doi: 10.1016/s0960-894x(03)00166-5. Bioorg Med Chem Lett. 2003. PMID: 12668014

3

Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking.

Carbone V, Ishikura S, Hara A, El-Kabbani O. Carbone V, et al. Among authors: hara a. Bioorg Med Chem. 2005 Jan 17;13(2):301-12. doi: 10.1016/j.bmc.2004.10.030. Bioorg Med Chem. 2005. PMID: 15598553

4

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.

Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: hara a. Med Chem. 2007 Nov;3(6):546-50. doi: 10.2174/157340607782360399. Med Chem. 2007. PMID: 18045204

5

Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.

Dhagat U, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: hara a. Bioorg Med Chem. 2008 Mar 15;16(6):3245-54. doi: 10.1016/j.bmc.2007.12.016. Epub 2007 Dec 15. Bioorg Med Chem. 2008. PMID: 18165015

6

Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid.

Dhagat U, Endo S, Sumii R, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: hara a. J Med Chem. 2008 Aug 14;51(15):4844-8. doi: 10.1021/jm8003575. Epub 2008 Jul 12. J Med Chem. 2008. PMID: 18620380

7

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Carbone V, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Among authors: hara a. Arch Biochem Biophys. 2008 Nov 1;479(1):82-7. doi: 10.1016/j.abb.2008.08.014. Epub 2008 Aug 28. Arch Biochem Biophys. 2008. PMID: 18782556

8

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.

Carbone V, Zhao HT, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Among authors: hara a. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. doi: 10.1016/j.bmc.2008.12.024. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19121944

9

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

Dhagat U, Endo S, Mamiya H, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: hara a. Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):257-65. doi: 10.1107/S0907444908044028. Epub 2009 Feb 20. Acta Crystallogr D Biol Crystallogr. 2009. PMID: 19237748

10

Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).

El-Kabbani O, Scammells PJ, Gosling J, Dhagat U, Endo S, Matsunaga T, Soda M, Hara A. El-Kabbani O, et al. Among authors: hara a. J Med Chem. 2009 May 28;52(10):3259-64. doi: 10.1021/jm9001633. J Med Chem. 2009. PMID: 19397269

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