Okuhira K - Search Results

1

Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis.

Kim S, Ohoka N, Okuhira K, Sai K, Nishimaki-Mogami T, Naito M. Kim S, et al. Among authors: okuhira k. Cancer Sci. 2010 Nov;101(11):2425-9. doi: 10.1111/j.1349-7006.2010.01697.x. Cancer Sci. 2010. PMID: 20825417 Free PMC article.

2

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

Okuhira K, Ohoka N, Sai K, Nishimaki-Mogami T, Itoh Y, Ishikawa M, Hashimoto Y, Naito M. Okuhira K, et al. FEBS Lett. 2011 Apr 20;585(8):1147-52. doi: 10.1016/j.febslet.2011.03.019. Epub 2011 Mar 21. FEBS Lett. 2011. PMID: 21414315 Free article.

3

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami T, Okuda H, Kurihara M, Naito M. Okuhira K, et al. Cancer Sci. 2013 Nov;104(11):1492-8. doi: 10.1111/cas.12272. Epub 2013 Oct 11. Cancer Sci. 2013. PMID: 23992566 Free PMC article.

4

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

Demizu Y, Okuhira K, Motoi H, Ohno A, Shoda T, Fukuhara K, Okuda H, Naito M, Kurihara M. Demizu Y, et al. Among authors: okuhira k. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1793-6. doi: 10.1016/j.bmcl.2011.11.086. Epub 2011 Nov 28. Bioorg Med Chem Lett. 2012. PMID: 22277276

5

HNF4α increases liver-specific human ATP-binding cassette transporter A1 expression and cholesterol efflux to apolipoprotein A-I in response to cholesterol depletion.

Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito M, Nishimaki-Mogami T. Ohoka N, et al. Among authors: okuhira k. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1005-14. doi: 10.1161/ATVBAHA.111.238360. Epub 2012 Jan 26. Arterioscler Thromb Vasc Biol. 2012. PMID: 22282358

6

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Kurihara M, Naito M. Okuhira K, et al. Methods Mol Biol. 2016;1366:549-560. doi: 10.1007/978-1-4939-3127-9_42. Methods Mol Biol. 2016. PMID: 26585163

7

Development of a peptide-based inducer of nuclear receptors degradation.

Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M. Demizu Y, et al. Among authors: okuhira k. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2655-8. doi: 10.1016/j.bmcl.2016.04.013. Epub 2016 Apr 7. Bioorg Med Chem Lett. 2016. PMID: 27086122

8

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, Ujikawa O, Shimokawa K, Sano O, Koyama R, Fujita H, Teratani M, Matsumoto H, Imaeda Y, Nara H, Cho N, Naito M. Ohoka N, et al. Among authors: okuhira k. J Biol Chem. 2017 Mar 17;292(11):4556-4570. doi: 10.1074/jbc.M116.768853. Epub 2017 Feb 2. J Biol Chem. 2017. PMID: 28154167 Free PMC article.

9

Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα.

Ohoka N, Yokoo H, Okuhira K, Demizu Y, Naito M. Ohoka N, et al. Among authors: okuhira k. Methods Mol Biol. 2022;2418:363-382. doi: 10.1007/978-1-0716-1920-9_20. Methods Mol Biol. 2022. PMID: 35119675

10

Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.

Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, Naito M. Ohoka N, et al. Among authors: okuhira k. Cell Death Dis. 2014 Nov 6;5(11):e1513. doi: 10.1038/cddis.2014.471. Cell Death Dis. 2014. PMID: 25375378 Free PMC article.

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