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The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.
El-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, Pohlmann L, King SB, DuMond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S. El-Armouche A, et al. Among authors: wittkopper k. Biochem Biophys Res Commun. 2010 Nov 12;402(2):340-4. doi: 10.1016/j.bbrc.2010.10.030. Epub 2010 Oct 12. Biochem Biophys Res Commun. 2010. PMID: 20946877
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. Among authors: wittkopper k. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
[Febuxostat].
Wittköpper K, Emons J, El-Armouche A. Wittköpper K, et al. Dtsch Med Wochenschr. 2011 Jun;136(23):1270-4. doi: 10.1055/s-0031-1272573. Epub 2011 May 23. Dtsch Med Wochenschr. 2011. PMID: 21607898 Review. German. No abstract available.
14 results