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An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T. Dinkova-Kostova AT, et al. Among authors: david e. J Biol Chem. 2010 Oct 29;285(44):33747-55. doi: 10.1074/jbc.M110.163485. Epub 2010 Aug 26. J Biol Chem. 2010. PMID: 20801881 Free PMC article.
Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.
Zheng S, Santosh Laxmi YR, David E, Dinkova-Kostova AT, Shiavoni KH, Ren Y, Zheng Y, Trevino I, Bumeister R, Ojima I, Wigley WC, Bliska JB, Mierke DF, Honda T. Zheng S, et al. Among authors: david e. J Med Chem. 2012 May 24;55(10):4837-46. doi: 10.1021/jm3003922. Epub 2012 May 7. J Med Chem. 2012. PMID: 22533790
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes.
Klunder JM, Hoermann M, Cywin CL, David E, Brickwood JR, Schwartz R, Barringer KJ, Pauletti D, Shih CK, Erickson DA, Sorge CL, Joseph DP, Hattox SE, Adams J, Grob PM. Klunder JM, et al. Among authors: david e. J Med Chem. 1998 Jul 30;41(16):2960-71. doi: 10.1021/jm9707028. J Med Chem. 1998. PMID: 9685235
Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.
Lazer ES, Miao CK, Cywin CL, Sorcek R, Wong HC, Meng Z, Potocki I, Hoermann M, Snow RJ, Tschantz MA, Kelly TA, McNeil DW, Coutts SJ, Churchill L, Graham AG, David E, Grob PM, Engel W, Meier H, Trummlitz G. Lazer ES, et al. Among authors: david e. J Med Chem. 1997 Mar 14;40(6):980-9. doi: 10.1021/jm9607010. J Med Chem. 1997. PMID: 9083488
Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus.
Fournier Dit Chabert J, Marquez B, Neville L, Joucla L, Broussous S, Bouhours P, David E, Pellet-Rostaing S, Marquet B, Moreau N, Lemaire M. Fournier Dit Chabert J, et al. Among authors: david e. Bioorg Med Chem. 2007 Jul 1;15(13):4482-97. doi: 10.1016/j.bmc.2007.04.023. Epub 2007 Apr 19. Bioorg Med Chem. 2007. PMID: 17498961
1,095 results