Pepper C - Search Results

1

Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription.

Buggins AG, Pepper C, Patten PE, Hewamana S, Gohil S, Moorhead J, Folarin N, Yallop D, Thomas NS, Mufti GJ, Fegan C, Devereux S. Buggins AG, et al. Among authors: pepper c. Cancer Res. 2010 Oct 1;70(19):7523-33. doi: 10.1158/0008-5472.CAN-10-1634. Epub 2010 Aug 24. Cancer Res. 2010. PMID: 20736369

2

Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia.

Pepper C, Thomas A, Hoy T, Fegan C, Bentley P. Pepper C, et al. Br J Haematol. 2001 Jul;114(1):70-7. doi: 10.1046/j.1365-2141.2001.02895.x. Br J Haematol. 2001. PMID: 11472347 Free article.

3

Retinoid-induced apoptosis in B-cell chronic lymphocytic leukaemia cells is mediated through caspase-3 activation and is independent of p53, the retinoic acid receptor, and differentiation.

Pepper C, Ali K, Thomas A, Hoy T, Fegan C, Chowdary P, Kell J, Bentley P. Pepper C, et al. Eur J Haematol. 2002 Oct;69(4):227-35. doi: 10.1034/j.1600-0609.2002.02799.x. Eur J Haematol. 2002. PMID: 12431242

4

The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro.

Pepper C, Thomas A, Hoy T, Milligan D, Bentley P, Fegan C. Pepper C, et al. Blood. 2003 Apr 1;101(7):2454-60. doi: 10.1182/blood-2002-07-1984. Epub 2002 Nov 21. Blood. 2003. PMID: 12446453 Free article.

5

Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.

Pepper C, Thomas A, Fegan C, Hoy T, Bentley P. Pepper C, et al. Leuk Lymphoma. 2003 Feb;44(2):337-42. doi: 10.1080/1042819021000029984. Leuk Lymphoma. 2003. PMID: 12688354

6

Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.

Pepper C, Thomas A, Hoy T, Tighe J, Culligan D, Fegan C, Bentley P. Pepper C, et al. Cell Cycle. 2003 Jan-Feb;2(1):53-8. Cell Cycle. 2003. PMID: 12695689

7

The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.

Pepper CJ, Hambly RM, Fegan CD, Delavault P, Thurston DE. Pepper CJ, et al. Cancer Res. 2004 Sep 15;64(18):6750-5. doi: 10.1158/0008-5472.CAN-04-1713. Cancer Res. 2004. PMID: 15374993

8

CD38+ chronic lymphocytic leukaemia cells co-express high levels of ZAP-70 and are functionally distinct from their CD38- counter-parts.

Pepper C, Brennan P, Alghazal S, Ward R, Pratt G, Starczynski J, Lin T, Rowntree C, Fegan C. Pepper C, et al. Leukemia. 2006 Apr;20(4):743-4. doi: 10.1038/sj.leu.2404133. Leukemia. 2006. PMID: 16452999 No abstract available.

9

The role of the bax gene polymorphism G(-248)A in chronic lymphocytic leukemia.

Fegan C, Starczynski J, Pratt G, Pepper C. Fegan C, et al. Among authors: pepper c. Leukemia. 2006 Aug;20(8):1460-1. doi: 10.1038/sj.leu.2404280. Epub 2006 Jun 8. Leukemia. 2006. PMID: 16761015 No abstract available.

10

The effect of immunoglobulin VH gene mutation status and other prognostic factors on the incidence of major infections in patients with chronic lymphocytic leukemia.

Francis S, Karanth M, Pratt G, Starczynski J, Hooper L, Fegan C, Pepper C, Valcarcel D, Milligan DW, Delgado J. Francis S, et al. Among authors: pepper c. Cancer. 2006 Sep 1;107(5):1023-33. doi: 10.1002/cncr.22094. Cancer. 2006. PMID: 16862572 Free article.

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