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Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death.
Kashyap T, Argueta C, Aboukameel A, Unger TJ, Klebanov B, Mohammad RM, Muqbil I, Azmi AS, Drolen C, Senapedis W, Lee M, Kauffman M, Shacham S, Landesman Y. Kashyap T, et al. Among authors: landesman y. Oncotarget. 2016 Nov 29;7(48):78883-78895. doi: 10.18632/oncotarget.12428. Oncotarget. 2016. PMID: 27713151 Free PMC article.
Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies.
Fischer MA, Friedlander SY, Arrate MP, Chang H, Gorska AE, Fuller LD, Ramsey HE, Kashyap T, Argueta C, Debler S, Byrne M, Villaume MT, Shaver AC, Senapedis W, Landesman Y, Baloglu E, Shacham S, Savona MR. Fischer MA, et al. Among authors: landesman y. Blood Adv. 2020 Feb 11;4(3):586-598. doi: 10.1182/bloodadvances.2019000359. Blood Adv. 2020. PMID: 32045477 Free PMC article.
Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.
Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour MR, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, Klebanov B, Landesman Y, Kauffman M, Shacham S, Kung AL, Wang JC, Letai A, Look AT. Etchin J, et al. Among authors: landesman y. Leukemia. 2016 Jan;30(1):190-9. doi: 10.1038/leu.2015.194. Epub 2015 Jul 23. Leukemia. 2016. PMID: 26202935 Free PMC article.
KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.
Etchin J, Berezovskaya A, Conway AS, Galinsky IA, Stone RM, Baloglu E, Senapedis W, Landesman Y, Kauffman M, Shacham S, Wang JC, Look AT. Etchin J, et al. Among authors: landesman y. Leukemia. 2017 Jan;31(1):143-150. doi: 10.1038/leu.2016.145. Epub 2016 May 23. Leukemia. 2017. PMID: 27211268 Free PMC article.
Phase 2 study of the Exportin 1 inhibitor selinexor in patients with recurrent gynecological malignancies.
Vergote IB, Lund B, Peen U, Umajuridze Z, Mau-Sorensen M, Kranich A, Van Nieuwenhuysen E, Haslund C, Nottrup T, Han SN, Concin N, Unger TJ, Chai Y, Au N, Rashal T, Joshi A, Crochiere M, Landesman Y, Shah J, Shacham S, Kauffman M, Mirza MR. Vergote IB, et al. Among authors: landesman y. Gynecol Oncol. 2020 Feb;156(2):308-314. doi: 10.1016/j.ygyno.2019.11.012. Epub 2019 Dec 9. Gynecol Oncol. 2020. PMID: 31822399 Clinical Trial.
126 results