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Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.
Fernandez PL, Dutra FF, Alves L, Figueiredo RT, Mourão-Sa D, Fortes GB, Bergstrand S, Lönn D, Cevallos RR, Pereira RMS, Lopes UG, Travassos LH, Paiva CN, Bozza MT. Fernandez PL, et al. Among authors: lonn d. J Biol Chem. 2010 Oct 22;285(43):32844-32851. doi: 10.1074/jbc.M110.146076. Epub 2010 Aug 20. J Biol Chem. 2010. PMID: 20729208 Free PMC article.