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Page 1
Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.
Fernandez PL, Dutra FF, Alves L, Figueiredo RT, Mourão-Sa D, Fortes GB, Bergstrand S, Lönn D, Cevallos RR, Pereira RMS, Lopes UG, Travassos LH, Paiva CN, Bozza MT. Fernandez PL, et al. Among authors: dutra ff. J Biol Chem. 2010 Oct 22;285(43):32844-32851. doi: 10.1074/jbc.M110.146076. Epub 2010 Aug 20. J Biol Chem. 2010. PMID: 20729208 Free PMC article.
Characterization of heme as activator of Toll-like receptor 4.
Figueiredo RT, Fernandez PL, Mourao-Sa DS, Porto BN, Dutra FF, Alves LS, Oliveira MF, Oliveira PL, Graça-Souza AV, Bozza MT. Figueiredo RT, et al. Among authors: dutra ff. J Biol Chem. 2007 Jul 13;282(28):20221-9. doi: 10.1074/jbc.M610737200. Epub 2007 May 14. J Biol Chem. 2007. PMID: 17502383 Free article.
TLR4 recognizes Pseudallescheria boydii conidia and purified rhamnomannans.
Figueiredo RT, Fernandez PL, Dutra FF, González Y, Lopes LC, Bittencourt VC, Sassaki GL, Barreto-Bergter E, Bozza MT. Figueiredo RT, et al. Among authors: dutra ff. J Biol Chem. 2010 Dec 24;285(52):40714-23. doi: 10.1074/jbc.M110.181255. Epub 2010 Oct 19. J Biol Chem. 2010. PMID: 20959459 Free PMC article.
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, Souto-Padron T, De Rosa MJ, Kelliher M, Golenbock D, Chan FK, Bozza MT. Fortes GB, et al. Among authors: dutra ff. Blood. 2012 Mar 8;119(10):2368-75. doi: 10.1182/blood-2011-08-375303. Epub 2012 Jan 18. Blood. 2012. PMID: 22262768 Free PMC article.
Oxidative stress fuels Trypanosoma cruzi infection in mice.
Paiva CN, Feijó DF, Dutra FF, Carneiro VC, Freitas GB, Alves LS, Mesquita J, Fortes GB, Figueiredo RT, Souza HS, Fantappié MR, Lannes-Vieira J, Bozza MT. Paiva CN, et al. Among authors: dutra ff. J Clin Invest. 2012 Jul;122(7):2531-42. doi: 10.1172/JCI58525. Epub 2012 Jun 25. J Clin Invest. 2012. PMID: 22728935 Free PMC article.
Binding of the wheat germ lectin to Cryptococcus neoformans chitooligomers affects multiple mechanisms required for fungal pathogenesis.
Fonseca FL, Guimarães AJ, Kmetzsch L, Dutra FF, Silva FD, Taborda CP, Araujo Gde S, Frases S, Staats CC, Bozza MT, Schrank A, Vainstein MH, Nimrichter L, Casadevall A, Rodrigues ML. Fonseca FL, et al. Among authors: dutra ff. Fungal Genet Biol. 2013 Nov;60:64-73. doi: 10.1016/j.fgb.2013.04.005. Epub 2013 Apr 19. Fungal Genet Biol. 2013. PMID: 23608320 Free PMC article.
Silymarin reduces profibrogenic cytokines and reverses hepatic fibrosis in chronic murine schistosomiasis.
Mata-Santos HA, Dutra FF, Rocha CC, Lino FG, Xavier FR, Chinalia LA, Hossy BH, Castelo-Branco MT, Teodoro AJ, Paiva CN, dos Santos Pyrrho A. Mata-Santos HA, et al. Among authors: dutra ff. Antimicrob Agents Chemother. 2014;58(4):2076-83. doi: 10.1128/AAC.01936-13. Epub 2014 Jan 21. Antimicrob Agents Chemother. 2014. PMID: 24449779 Free PMC article.
Heme on innate immunity and inflammation.
Dutra FF, Bozza MT. Dutra FF, et al. Front Pharmacol. 2014 May 27;5:115. doi: 10.3389/fphar.2014.00115. eCollection 2014. Front Pharmacol. 2014. PMID: 24904418 Free PMC article. Review.
Hemolysis-induced lethality involves inflammasome activation by heme.
Dutra FF, Alves LS, Rodrigues D, Fernandez PL, de Oliveira RB, Golenbock DT, Zamboni DS, Bozza MT. Dutra FF, et al. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4110-8. doi: 10.1073/pnas.1405023111. Epub 2014 Sep 15. Proc Natl Acad Sci U S A. 2014. PMID: 25225402 Free PMC article.
20 results