Lehr M - Search Results

1

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.

Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH. Ghomashchi F, et al. Among authors: lehr m. J Biol Chem. 2010 Nov 12;285(46):36100-11. doi: 10.1074/jbc.M110.165647. Epub 2010 Aug 11. J Biol Chem. 2010. PMID: 20705608 Free PMC article.

2

Metabolism of sumatriptan revisited.

Pöstges T, Lehr M. Pöstges T, et al. Among authors: lehr m. Pharmacol Res Perspect. 2023 Feb;11(1):e01051. doi: 10.1002/prp2.1051. Pharmacol Res Perspect. 2023. PMID: 36655303 Free PMC article.

3

Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.

Ludwig J, Bovens S, Brauch C, Elfringhoff AS, Lehr M. Ludwig J, et al. Among authors: lehr m. J Med Chem. 2006 Apr 20;49(8):2611-20. doi: 10.1021/jm051243a. J Med Chem. 2006. PMID: 16610804

4

1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility.

Fritsche A, Elfringhoff AS, Fabian J, Lehr M. Fritsche A, et al. Among authors: lehr m. Bioorg Med Chem. 2008 Apr 1;16(7):3489-500. doi: 10.1016/j.bmc.2008.02.019. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18321717

5

Design and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2alpha.

Hess M, Schulze Elfringhoff A, Lehr M. Hess M, et al. Among authors: lehr m. J Enzyme Inhib Med Chem. 2008 Dec;23(6):946-57. doi: 10.1080/14756360701810249. J Enzyme Inhib Med Chem. 2008. PMID: 18608744 Free article.

6

1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues.

Bovens S, Kaptur M, Elfringhoff AS, Lehr M. Bovens S, et al. Among authors: lehr m. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2107-11. doi: 10.1016/j.bmcl.2009.03.019. Epub 2009 Mar 10. Bioorg Med Chem Lett. 2009. PMID: 19327988

7

1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.

Forster L, Ludwig J, Kaptur M, Bovens S, Elfringhoff AS, Holtfrerich A, Lehr M. Forster L, et al. Among authors: lehr m. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. doi: 10.1016/j.bmc.2009.11.028. Epub 2009 Nov 17. Bioorg Med Chem. 2010. PMID: 20005725

8

1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.

Drews A, Bovens S, Roebrock K, Sunderkötter C, Reinhardt D, Schäfers M, van der Velde A, Schulze Elfringhoff A, Fabian J, Lehr M. Drews A, et al. Among authors: lehr m. J Med Chem. 2010 Jul 22;53(14):5165-78. doi: 10.1021/jm1001088. J Med Chem. 2010. PMID: 20583844

9

1-(5-Carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α: effect of substituents in position 3 of the indole scaffold on inhibitory potency, metabolic stability, solubility, and bioavailability.

Bovens S, Schulze Elfringhoff A, Kaptur M, Reinhardt D, Schäfers M, Lehr M. Bovens S, et al. Among authors: lehr m. J Med Chem. 2010 Dec 9;53(23):8298-308. doi: 10.1021/jm101094p. Epub 2010 Nov 10. J Med Chem. 2010. PMID: 21067218

10

Structure-activity relationship studies on 1-(5-carboxyindol-1-yl)-propan-2-one inhibitors of human cytosolic phospholipase A2α: variation of the activated ketone moiety.

Kaptur M, Elfringhoff AS, Lehr M. Kaptur M, et al. Among authors: lehr m. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1773-6. doi: 10.1016/j.bmcl.2011.01.085. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316224

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