Gersting SW - Search Results

1

New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.

Lagler FB, Gersting SW, Zsifkovits C, Steinbacher A, Eichinger A, Danecka MK, Staudigl M, Fingerhut R, Glossmann H, Muntau AC. Lagler FB, et al. Among authors: gersting sw. Biochem Pharmacol. 2010 Nov 15;80(10):1563-71. doi: 10.1016/j.bcp.2010.07.042. Epub 2010 Aug 10. Biochem Pharmacol. 2010. PMID: 20705059

2

Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instability.

Gersting SW, Kemter KF, Staudigl M, Messing DD, Danecka MK, Lagler FB, Sommerhoff CP, Roscher AA, Muntau AC. Gersting SW, et al. Am J Hum Genet. 2008 Jul;83(1):5-17. doi: 10.1016/j.ajhg.2008.05.013. Epub 2008 Jun 5. Am J Hum Genet. 2008. PMID: 18538294 Free PMC article.

3

Protein misfolding is the molecular mechanism underlying MCADD identified in newborn screening.

Maier EM, Gersting SW, Kemter KF, Jank JM, Reindl M, Messing DD, Truger MS, Sommerhoff CP, Muntau AC. Maier EM, et al. Among authors: gersting sw. Hum Mol Genet. 2009 May 1;18(9):1612-23. doi: 10.1093/hmg/ddp079. Epub 2009 Feb 18. Hum Mol Genet. 2009. PMID: 19224950 Free PMC article.

4

Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo.

Gersting SW, Lagler FB, Eichinger A, Kemter KF, Danecka MK, Messing DD, Staudigl M, Domdey KA, Zsifkovits C, Fingerhut R, Glossmann H, Roscher AA, Muntau AC. Gersting SW, et al. Hum Mol Genet. 2010 May 15;19(10):2039-49. doi: 10.1093/hmg/ddq085. Epub 2010 Feb 23. Hum Mol Genet. 2010. PMID: 20179079 Free article.

5

Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactor.

Gersting SW, Staudigl M, Truger MS, Messing DD, Danecka MK, Sommerhoff CP, Kemter KF, Muntau AC. Gersting SW, et al. J Biol Chem. 2010 Oct 1;285(40):30686-97. doi: 10.1074/jbc.M110.124016. Epub 2010 Jul 27. J Biol Chem. 2010. PMID: 20667834 Free PMC article.

6

Phenylketonuria as a model for protein misfolding diseases and for the development of next generation orphan drugs for patients with inborn errors of metabolism.

Muntau AC, Gersting SW. Muntau AC, et al. Among authors: gersting sw. J Inherit Metab Dis. 2010 Dec;33(6):649-58. doi: 10.1007/s10545-010-9185-4. Epub 2010 Sep 8. J Inherit Metab Dis. 2010. PMID: 20824346 Review.

7

The interplay between genotype, metabolic state and cofactor treatment governs phenylalanine hydroxylase function and drug response.

Staudigl M, Gersting SW, Danecka MK, Messing DD, Woidy M, Pinkas D, Kemter KF, Blau N, Muntau AC. Staudigl M, et al. Among authors: gersting sw. Hum Mol Genet. 2011 Jul 1;20(13):2628-41. doi: 10.1093/hmg/ddr165. Epub 2011 Apr 28. Hum Mol Genet. 2011. PMID: 21527427 Free article.

8

Identification of a new fatty acid synthesis-transport machinery at the peroxisomal membrane.

Hillebrand M, Gersting SW, Lotz-Havla AS, Schäfer A, Rosewich H, Valerius O, Muntau AC, Gärtner J. Hillebrand M, et al. Among authors: gersting sw. J Biol Chem. 2012 Jan 2;287(1):210-221. doi: 10.1074/jbc.M111.272732. Epub 2011 Nov 1. J Biol Chem. 2012. PMID: 22045812 Free PMC article.

9

Bioluminescence resonance energy transfer: an emerging tool for the detection of protein-protein interaction in living cells.

Gersting SW, Lotz-Havla AS, Muntau AC. Gersting SW, et al. Methods Mol Biol. 2012;815:253-63. doi: 10.1007/978-1-61779-424-7_19. Methods Mol Biol. 2012. PMID: 22130997

10

Novel pharmacological chaperones that correct phenylketonuria in mice.

Santos-Sierra S, Kirchmair J, Perna AM, Reiss D, Kemter K, Röschinger W, Glossmann H, Gersting SW, Muntau AC, Wolber G, Lagler FB. Santos-Sierra S, et al. Among authors: gersting sw. Hum Mol Genet. 2012 Apr 15;21(8):1877-87. doi: 10.1093/hmg/dds001. Epub 2012 Jan 13. Hum Mol Genet. 2012. PMID: 22246293

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