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Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Booker ML, et al. Among authors: janse cj. J Biol Chem. 2010 Oct 22;285(43):33054-33064. doi: 10.1074/jbc.M110.162081. Epub 2010 Aug 11. J Biol Chem. 2010. PMID: 20702404 Free PMC article.
Plasmodium post-genomics: better the bug you know?
Kooij TW, Janse CJ, Waters AP. Kooij TW, et al. Among authors: janse cj. Nat Rev Microbiol. 2006 May;4(5):344-57. doi: 10.1038/nrmicro1392. Nat Rev Microbiol. 2006. PMID: 16582929 Review.
Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.
van Schaijk BC, Janse CJ, van Gemert GJ, van Dijk MR, Gego A, Franetich JF, van de Vegte-Bolmer M, Yalaoui S, Silvie O, Hoffman SL, Waters AP, Mazier D, Sauerwein RW, Khan SM. van Schaijk BC, et al. Among authors: janse cj. PLoS One. 2008;3(10):e3549. doi: 10.1371/journal.pone.0003549. Epub 2008 Oct 28. PLoS One. 2008. PMID: 18958160 Free PMC article.
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA. Yu M, et al. Among authors: janse cj. Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001. Cell Host Microbe. 2008. PMID: 19064257 Free PMC article.
The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission.
Vega-Rodríguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodríguez-Orengo JF, Srinivasan P, Jacobs-Lorena M, Serrano AE. Vega-Rodríguez J, et al. Among authors: janse cj. PLoS Pathog. 2009 Feb;5(2):e1000302. doi: 10.1371/journal.ppat.1000302. Epub 2009 Feb 20. PLoS Pathog. 2009. PMID: 19229315 Free PMC article.
265 results