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Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects.
Marshall GM, Gherardi S, Xu N, Neiron Z, Trahair T, Scarlett CJ, Chang DK, Liu PY, Jankowski K, Iraci N, Haber M, Norris MD, Keating J, Sekyere E, Jonquieres G, Stossi F, Katzenellenbogen BS, Biankin AV, Perini G, Liu T. Marshall GM, et al. Among authors: iraci n. Oncogene. 2010 Nov 4;29(44):5957-68. doi: 10.1038/onc.2010.332. Epub 2010 Aug 9. Oncogene. 2010. PMID: 20697349
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, Haber M, Norris MD, Biankin AV, Perini G, Liu T. Marshall GM, et al. Among authors: iraci n. PLoS Genet. 2011 Jun;7(6):e1002135. doi: 10.1371/journal.pgen.1002135. Epub 2011 Jun 16. PLoS Genet. 2011. PMID: 21698133 Free PMC article.
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.
Matera A, Compagnion AC, Pedicone C, Kotah JM, Ivanov A, Monsorno K, Labouèbe G, Leggio L, Pereira-Iglesias M, Beule D, Mansuy-Aubert V, Williams TL, Iraci N, Sierra A, Marro SG, Goate AM, Eggen BJL, Kerr WG, Paolicelli RC. Matera A, et al. Among authors: iraci n. Immunity. 2024 Dec 9:S1074-7613(24)00513-2. doi: 10.1016/j.immuni.2024.11.003. Online ahead of print. Immunity. 2024. PMID: 39657671 Free article.
KCNT1 Channel Blockers: A Medicinal Chemistry Perspective.
Di Matteo F, Mancuso F, Turcio R, Ciaglia T, Stagno C, Di Chio C, Campiglia P, Bertamino A, Giofrè SV, Ostacolo C, Iraci N. Di Matteo F, et al. Among authors: iraci n. Molecules. 2024 Jun 20;29(12):2940. doi: 10.3390/molecules29122940. Molecules. 2024. PMID: 38931004 Free PMC article. Review.
Structural features and antiproliferative activity of Pd(II) complexes with halogenated ligands: a comparative study between Schiff base and reduced Schiff base complexes.
Forooghi K, Amiri Rudbari H, Stagno C, Iraci N, Cuevas-Vicario JV, Kordestani N, Schirmeister T, Efferth T, Omer EA, Moini N, Aryaeifar M, Blacque O, Azadbakht R, Micale N. Forooghi K, et al. Among authors: iraci n. Dalton Trans. 2024 Jun 25;53(25):10571-10591. doi: 10.1039/d4dt00132j. Dalton Trans. 2024. PMID: 38855858
In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel.
Iraci N, Carotenuto L, Ciaglia T, Belperio G, Di Matteo F, Mosca I, Carleo G, Giovanna Basilicata M, Ambrosino P, Turcio R, Puzo D, Pepe G, Gomez-Monterrey I, Soldovieri MV, Di Sarno V, Campiglia P, Miceli F, Bertamino A, Ostacolo C, Taglialatela M. Iraci N, et al. J Med Chem. 2024 Jun 13;67(11):9124-9149. doi: 10.1021/acs.jmedchem.4c00268. Epub 2024 May 23. J Med Chem. 2024. PMID: 38782404 Free PMC article.
102 results