Knox AJ - Search Results

1

Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.

Hintersteiner M, Ambrus G, Bednenko J, Schmied M, Knox AJ, Meisner NC, Gstach H, Seifert JM, Singer EL, Gerace L, Auer M. Hintersteiner M, et al. Among authors: knox aj. ACS Chem Biol. 2010 Oct 15;5(10):967-79. doi: 10.1021/cb100094k. ACS Chem Biol. 2010. PMID: 20677820 Free PMC article.

2

Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening.

Hintersteiner M, Knox AJ, Mudd G, Auer M. Hintersteiner M, et al. Among authors: knox aj. J Chem Biol. 2012 Apr;5(2):63-79. doi: 10.1007/s12154-011-0071-9. Epub 2012 Jan 3. J Chem Biol. 2012. PMID: 23284589 Free PMC article.

3

Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.

Carr M, Knox AJS, Nevin DK, O'Boyle N, Wang S, Egan B, McCabe T, Twamley B, Zisterer DM, Lloyd DG, Meegan MJ. Carr M, et al. Bioorg Med Chem. 2020 Mar 1;28(5):115261. doi: 10.1016/j.bmc.2019.115261. Epub 2019 Dec 24. Bioorg Med Chem. 2020. PMID: 31987694

4

Estrogen receptors: molecular interactions, virtual screening and future prospects.

Knox AJ, Meegan MJ, Lloyd DG. Knox AJ, et al. Curr Top Med Chem. 2006;6(3):217-43. doi: 10.2174/156802606776173438. Curr Top Med Chem. 2006. PMID: 16515479 Review.

5

Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

Smith HM, Knox AJ, Zisterer DM, Lloyd DG, Meegan MJ. Smith HM, et al. Among authors: knox aj. Med Chem. 2007 Mar;3(2):135-55. doi: 10.2174/157340607780059503. Med Chem. 2007. PMID: 17348852

6

Target specific virtual screening: optimization of an estrogen receptor screening platform.

Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG. Knox AJ, et al. J Med Chem. 2007 Nov 1;50(22):5301-10. doi: 10.1021/jm0700262. Epub 2007 Oct 5. J Med Chem. 2007. PMID: 17918820

7

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.

Meegan MJ, Barrett I, Zimmermann J, Knox AJ, Zisterer DM, Lloyd DG. Meegan MJ, et al. Among authors: knox aj. J Enzyme Inhib Med Chem. 2007 Oct;22(5):655-66. doi: 10.1080/14756360701503232. J Enzyme Inhib Med Chem. 2007. PMID: 18035834 Free article.

8

Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells.

Meegan MJ, Carr M, Knox AJ, Zisterer DM, Lloyd DG. Meegan MJ, et al. Among authors: knox aj. J Enzyme Inhib Med Chem. 2008 Oct;23(5):668-85. doi: 10.1080/14756360802469127. J Enzyme Inhib Med Chem. 2008. PMID: 18821256 Free article.

9

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

Barrett I, Meegan MJ, Hughes RB, Carr M, Knox AJ, Artemenko N, Golfis G, Zisterer DM, Lloyd DG. Barrett I, et al. Among authors: knox aj. Bioorg Med Chem. 2008 Nov 1;16(21):9554-73. doi: 10.1016/j.bmc.2008.09.035. Epub 2008 Sep 16. Bioorg Med Chem. 2008. PMID: 18835176

10

Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.

Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG. Knox AJ, et al. J Med Chem. 2009 Apr 23;52(8):2177-80. doi: 10.1021/jm801569z. J Med Chem. 2009. PMID: 19331414

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