Penning TM - Search Results

1

Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors.

Steckelbroeck S, Lütjohann D, Bauman DR, Ludwig M, Friedl A, Hans VH, Penning TM, Klingmüller D. Steckelbroeck S, et al. Among authors: penning tm. Biochim Biophys Acta. 2010 Nov;1801(11):1221-31. doi: 10.1016/j.bbalip.2010.07.005. Epub 2010 Jul 29. Biochim Biophys Acta. 2010. PMID: 20673851 Free PMC article.

2

The aldo-keto reductase superfamily homepage.

Hyndman D, Bauman DR, Heredia VV, Penning TM. Hyndman D, et al. Among authors: penning tm. Chem Biol Interact. 2003 Feb 1;143-144:621-31. doi: 10.1016/s0009-2797(02)00193-x. Chem Biol Interact. 2003. PMID: 12604248

3

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR, Penning TM. Rizner TL, et al. Among authors: penning tm. Endocrinology. 2003 Jul;144(7):2922-32. doi: 10.1210/en.2002-0032. Endocrinology. 2003. PMID: 12810547

4

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM. Steckelbroeck S, et al. Among authors: penning tm. J Biol Chem. 2004 Mar 12;279(11):10784-95. doi: 10.1074/jbc.M313308200. Epub 2003 Dec 12. J Biol Chem. 2004. PMID: 14672942 Free article.

5

Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.

Penning TM, Jin Y, Steckelbroeck S, Lanisnik Rizner T, Lewis M. Penning TM, et al. Mol Cell Endocrinol. 2004 Feb 27;215(1-2):63-72. doi: 10.1016/j.mce.2003.11.006. Mol Cell Endocrinol. 2004. PMID: 15026176 Review.

6

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.

Steckelbroeck S, Jin Y, Oyesanmi B, Kloosterboer HJ, Penning TM. Steckelbroeck S, et al. Among authors: penning tm. Mol Pharmacol. 2004 Dec;66(6):1702-11. doi: 10.1124/mol.104.004515. Epub 2004 Sep 21. Mol Pharmacol. 2004. PMID: 15383625

7

Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes.

Bauman DR, Rudnick SI, Szewczuk LM, Jin Y, Gopishetty S, Penning TM. Bauman DR, et al. Among authors: penning tm. Mol Pharmacol. 2005 Jan;67(1):60-8. doi: 10.1124/mol.104.006569. Epub 2004 Oct 8. Mol Pharmacol. 2005. PMID: 15475569

8

Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate.

Lin HK, Steckelbroeck S, Fung KM, Jones AN, Penning TM. Lin HK, et al. Among authors: penning tm. Steroids. 2004 Dec;69(13-14):795-801. doi: 10.1016/j.steroids.2004.09.014. Steroids. 2004. PMID: 15582534

9

The roles of aldo-keto reductases in steroid hormone action.

Bauman DR, Steckelbroeck S, Penning TM. Bauman DR, et al. Among authors: penning tm. Drug News Perspect. 2004 Nov;17(9):563-78. doi: 10.1358/dnp.2004.17.9.872570. Drug News Perspect. 2004. PMID: 15645014 Review.

10

Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease.

Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM. Bauman DR, et al. Among authors: penning tm. Mol Endocrinol. 2006 Feb;20(2):444-58. doi: 10.1210/me.2005-0287. Epub 2005 Sep 22. Mol Endocrinol. 2006. PMID: 16179381

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