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SIRT1 is essential for normal cognitive function and synaptic plasticity.
Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. Michán S, et al. Among authors: lewis k. J Neurosci. 2010 Jul 21;30(29):9695-707. doi: 10.1523/JNEUROSCI.0027-10.2010. J Neurosci. 2010. PMID: 20660252 Free PMC article.
Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Baur JA, et al. Among authors: lewis k. Nature. 2006 Nov 16;444(7117):337-42. doi: 10.1038/nature05354. Epub 2006 Nov 1. Nature. 2006. PMID: 17086191 Free PMC article.
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R. Pearson KJ, et al. Among authors: lewis kn. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2325-30. doi: 10.1073/pnas.0712162105. Epub 2008 Feb 19. Proc Natl Acad Sci U S A. 2008. PMID: 18287083 Free PMC article.
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Pearson KJ, et al. Among authors: lewis kn. Cell Metab. 2008 Aug;8(2):157-68. doi: 10.1016/j.cmet.2008.06.011. Epub 2008 Jul 3. Cell Metab. 2008. PMID: 18599363 Free PMC article.
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R. Jimenez-Gomez Y, et al. Among authors: lewis k. Cell Metab. 2013 Oct 1;18(4):533-45. doi: 10.1016/j.cmet.2013.09.004. Cell Metab. 2013. PMID: 24093677 Free PMC article.
Perinatal exercise improves glucose homeostasis in adult offspring.
Carter LG, Lewis KN, Wilkerson DC, Tobia CM, Ngo Tenlep SY, Shridas P, Garcia-Cazarin ML, Wolff G, Andrade FH, Charnigo RJ, Esser KA, Egan JM, de Cabo R, Pearson KJ. Carter LG, et al. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1061-8. doi: 10.1152/ajpendo.00213.2012. Epub 2012 Aug 28. Am J Physiol Endocrinol Metab. 2012. PMID: 22932781 Free PMC article.
Analytical Quality Evaluation of the Tox21 Compound Library.
Richard AM, Tao D, LeClair CA, Leister W, Tretyakov KV, White E 5th, Lewis KC, Sefler A, Shinn P, Collins BJ, Nguyen DT, Ye L, Zhao T, Xu T, Williams AJ, Waidyanatha S, Thomas RS, Tice R, Simeonov A, Huang R. Richard AM, et al. Among authors: lewis kc. Chem Res Toxicol. 2025 Jan 20;38(1):15-41. doi: 10.1021/acs.chemrestox.4c00330. Epub 2024 Dec 31. Chem Res Toxicol. 2025. PMID: 39829241 Review.
2,574 results