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Page 1
Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
Fadden P, Huang KH, Veal JM, Steed PM, Barabasz AF, Foley B, Hu M, Partridge JM, Rice J, Scott A, Dubois LG, Freed TA, Silinski MA, Barta TE, Hughes PF, Ommen A, Ma W, Smith ED, Spangenberg AW, Eaves J, Hanson GJ, Hinkley L, Jenks M, Lewis M, Otto J, Pronk GJ, Verleysen K, Haystead TA, Hall SE. Fadden P, et al. Among authors: smith ed. Chem Biol. 2010 Jul 30;17(7):686-94. doi: 10.1016/j.chembiol.2010.04.015. Chem Biol. 2010. PMID: 20659681
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, Freed T, Steed PM, Ommen AJ, Smith ED, Hughes PF, Woodward AR, Hanson GJ, McCall WS, Markworth CJ, Hinkley L, Jenks M, Geng L, Lewis M, Otto J, Pronk B, Verleysen K, Hall SE. Huang KH, et al. Among authors: smith ed. J Med Chem. 2009 Jul 23;52(14):4288-305. doi: 10.1021/jm900230j. J Med Chem. 2009. PMID: 19552433
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.
Huang KH, Barta TE, Rice JW, Smith ED, Ommen AJ, Ma W, Veal JM, Fadden RP, Barabasz AF, Foley BE, Hughes PF, Hanson GJ, Markworth CJ, Silinski M, Partridge JM, Steed PM, Hall SE. Huang KH, et al. Among authors: smith ed. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2550-4. doi: 10.1016/j.bmcl.2012.01.137. Epub 2012 Feb 15. Bioorg Med Chem Lett. 2012. PMID: 22386527
A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay.
Smith ED, Ariane Vinson N, Zhong D, Berrang BD, Catanzaro JL, Thomas JB, Navarro HA, Gilmour BP, Deschamps J, Carroll FI. Smith ED, et al. Bioorg Med Chem. 2008 Jan 15;16(2):822-9. doi: 10.1016/j.bmc.2007.10.023. Epub 2007 Oct 13. Bioorg Med Chem. 2008. PMID: 17976996 Free PMC article.
Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.
Meisner JK, Renberg A, Smith ED, Tsan YC, Elder B, Bullard A, Merritt O, Zheng SL, Lakdawala N, Owens A, Ryan TD, Miller EM, Rossano J, Lin KY, Claggett B, Ashley E, Michels M, Lampert R, Stendahl JC, Abrahams D, Semsarian C, Parikh VN, Wheeler M, Ingles J, Day SM, Saberi S, Russell MW, Previs M, Ho C, Ware JS, Helms AS. Meisner JK, et al. Among authors: smith ed. Circulation. 2024 Dec 5. doi: 10.1161/CIRCULATIONAHA.124.069398. Online ahead of print. Circulation. 2024. PMID: 39633578
Coping and learning to Manage Stress with cystic fibrosis (CALM): A multisite telehealth randomized controlled trial to reduce depression and anxiety symptoms in adults with cystic fibrosis.
Bathgate CJ, Smith ED, Murphy NH, Quittner AL, Riekert KA, Goralski JL, Holm KE. Bathgate CJ, et al. Among authors: smith ed. J Cyst Fibros. 2024 Nov 24:S1569-1993(24)01810-1. doi: 10.1016/j.jcf.2024.11.002. Online ahead of print. J Cyst Fibros. 2024. PMID: 39581781
256 results