Scott A - Search Results

1

Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.

Fadden P, Huang KH, Veal JM, Steed PM, Barabasz AF, Foley B, Hu M, Partridge JM, Rice J, Scott A, Dubois LG, Freed TA, Silinski MA, Barta TE, Hughes PF, Ommen A, Ma W, Smith ED, Spangenberg AW, Eaves J, Hanson GJ, Hinkley L, Jenks M, Lewis M, Otto J, Pronk GJ, Verleysen K, Haystead TA, Hall SE. Fadden P, et al. Among authors: scott a. Chem Biol. 2010 Jul 30;17(7):686-94. doi: 10.1016/j.chembiol.2010.04.015. Chem Biol. 2010. PMID: 20659681

2

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, Freed T, Steed PM, Ommen AJ, Smith ED, Hughes PF, Woodward AR, Hanson GJ, McCall WS, Markworth CJ, Hinkley L, Jenks M, Geng L, Lewis M, Otto J, Pronk B, Verleysen K, Hall SE. Huang KH, et al. Among authors: scott a. J Med Chem. 2009 Jul 23;52(14):4288-305. doi: 10.1021/jm900230j. J Med Chem. 2009. PMID: 19552433

3

Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib.

Rice JW, Veal JM, Barabasz A, Foley B, Fadden P, Scott A, Huang K, Steed P, Hall S. Rice JW, et al. Among authors: scott a. Oncol Res. 2009;18(5-6):229-42. doi: 10.3727/096504009x12596189659240. Oncol Res. 2009. PMID: 20225761

4

The use of high-content screening for the discovery and characterization of compounds that modulate mitotic index and cell cycle progression by differing mechanisms of action.

Barabasz A, Foley B, Otto JC, Scott A, Rice J. Barabasz A, et al. Among authors: scott a. Assay Drug Dev Technol. 2006 Apr;4(2):153-63. doi: 10.1089/adt.2006.4.153. Assay Drug Dev Technol. 2006. PMID: 16712419

5

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Putcha P, et al. Among authors: scott a. J Pharmacol Exp Ther. 2010 Mar;332(3):849-57. doi: 10.1124/jpet.109.158436. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934398 Free PMC article.

6

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers.

Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N, Solit DB. Chandarlapaty S, et al. Among authors: scott a. Clin Cancer Res. 2008 Jan 1;14(1):240-8. doi: 10.1158/1078-0432.CCR-07-1667. Clin Cancer Res. 2008. PMID: 18172276 Free PMC article.

7

Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex.

Khan HF, Dutta S, Scott AN, Xiao S, Yadav S, Chen X, Aryal UK, Kinzer-Ursem TL, Rochet JC, Jayant K. Khan HF, et al. Among authors: scott an. Nat Commun. 2024 Dec 30;15(1):10775. doi: 10.1038/s41467-024-54945-0. Nat Commun. 2024. PMID: 39737978 Free PMC article.

8

Social context modulates active avoidance: Contributions of the anterior cingulate cortex in male and female rats.

Ruble S, Payne K, Kramer C, West L, Ness H, Erickson G, Scott A, Diehl MM. Ruble S, et al. Among authors: scott a. Neurobiol Stress. 2024 Dec 5;34:100702. doi: 10.1016/j.ynstr.2024.100702. eCollection 2025 Jan. Neurobiol Stress. 2024. PMID: 39737250 Free PMC article.

9

Do biopsychosocial factors predict the level of physical activity in individuals with persistent shoulder pain?

Rosa DP, Beaulieu-Bonneau S, Scott A, Roy JS. Rosa DP, et al. Among authors: scott a. Musculoskelet Sci Pract. 2024 Dec 18;75:103247. doi: 10.1016/j.msksp.2024.103247. Online ahead of print. Musculoskelet Sci Pract. 2024. PMID: 39718267

10

Comparative analysis of neural crest development in the chick and mouse.

Morrison JA, Pushel I, McLennan R, McKinney MC, Gogol MM, Scott A, Krumlauf R, Kulesa PM. Morrison JA, et al. Among authors: scott a. Dev Biol. 2024 Dec 21;519:142-149. doi: 10.1016/j.ydbio.2024.12.014. Online ahead of print. Dev Biol. 2024. PMID: 39716593

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