Millán JL - Search Results

1

Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening.

Chung TD, Sergienko E, Millán JL. Chung TD, et al. Among authors: millan jl. Molecules. 2010 Apr 27;15(5):3010-37. doi: 10.3390/molecules15053010. Molecules. 2010. PMID: 20657462 Free PMC article. Review.

2

Alkaline phosphatase as a reporter of cancerous transformation.

Millán JL. Millán JL. Clin Chim Acta. 1992 Jul 31;209(1-2):123-9. doi: 10.1016/0009-8981(92)90343-o. Clin Chim Acta. 1992. PMID: 1395034 Review.

3

Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment.

Hoylaerts MF, Ding L, Narisawa S, Van Kerckhoven S, Millan JL. Hoylaerts MF, et al. Among authors: millan jl. Biochemistry. 2006 Aug 15;45(32):9756-66. doi: 10.1021/bi052471+. Biochemistry. 2006. PMID: 16893177

4

Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.

Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millán JL. Narisawa S, et al. Among authors: millan jl. J Bone Miner Res. 2007 Nov;22(11):1700-10. doi: 10.1359/jbmr.070714. J Bone Miner Res. 2007. PMID: 17638573 Free article.

5

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Sidique S, Ardecky R, Su Y, Narisawa S, Brown B, Millán JL, Sergienko E, Cosford ND. Sidique S, et al. Among authors: millan jl. Bioorg Med Chem Lett. 2009 Jan 1;19(1):222-5. doi: 10.1016/j.bmcl.2008.10.107. Epub 2008 Oct 31. Bioorg Med Chem Lett. 2009. PMID: 19038545 Free PMC article.

6

Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.

Sergienko E, Su Y, Chan X, Brown B, Hurder A, Narisawa S, Millán JL. Sergienko E, et al. Among authors: millan jl. J Biomol Screen. 2009 Aug;14(7):824-37. doi: 10.1177/1087057109338517. Epub 2009 Jun 25. J Biomol Screen. 2009. PMID: 19556612 Free PMC article.

7

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Dahl R, Sergienko EA, Su Y, Mostofi YS, Yang L, Simao AM, Narisawa S, Brown B, Mangravita-Novo A, Vicchiarelli M, Smith LH, O'Neill WC, Millán JL, Cosford ND. Dahl R, et al. Among authors: millan jl. J Med Chem. 2009 Nov 12;52(21):6919-25. doi: 10.1021/jm900383s. J Med Chem. 2009. PMID: 19821572 Free PMC article.

8

Design and synthesis of selective inhibitors of placental alkaline phosphatase.

Lanier M, Sergienko E, Simão AM, Su Y, Chung T, Millán JL, Cashman JR. Lanier M, et al. Among authors: millan jl. Bioorg Med Chem. 2010 Jan 15;18(2):573-9. doi: 10.1016/j.bmc.2009.12.012. Epub 2009 Dec 11. Bioorg Med Chem. 2010. PMID: 20031422 Free PMC article.

9

High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action.

Sergienko EA, Millán JL. Sergienko EA, et al. Among authors: millan jl. Nat Protoc. 2010 Aug;5(8):1431-9. doi: 10.1038/nprot.2010.86. Epub 2010 Jul 15. Nat Protoc. 2010. PMID: 20671726 Free PMC article.

10

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.

Kiffer-Moreira T, Yadav MC, Zhu D, Narisawa S, Sheen C, Stec B, Cosford ND, Dahl R, Farquharson C, Hoylaerts MF, Macrae VE, Millán JL. Kiffer-Moreira T, et al. Among authors: millan jl. J Bone Miner Res. 2013 Jan;28(1):81-91. doi: 10.1002/jbmr.1733. J Bone Miner Res. 2013. PMID: 22887744 Free PMC article.

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