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Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: wadkins rm. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546
Modifications of human carboxylesterase for improved prodrug activation.
Hatfield JM, Wierdl M, Wadkins RM, Potter PM. Hatfield JM, et al. Among authors: wadkins rm. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1153-65. doi: 10.1517/17425255.4.9.1153. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721110 Free PMC article. Review.
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. Harel M, et al. Among authors: wadkins rm. Mol Pharmacol. 2005 Jun;67(6):1874-81. doi: 10.1124/mol.104.009944. Epub 2005 Mar 16. Mol Pharmacol. 2005. PMID: 15772291
53 results