Pitt SJ - Search Results

1

Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel.

Pitt SJ, Park KH, Nishi M, Urashima T, Aoki S, Yamazaki D, Ma J, Takeshima H, Sitsapesan R. Pitt SJ, et al. Biophys J. 2010 Jul 21;99(2):417-26. doi: 10.1016/j.bpj.2010.04.051. Biophys J. 2010. PMID: 20643059 Free PMC article.

2

Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel.

Venturi E, Mio K, Nishi M, Ogura T, Moriya T, Pitt SJ, Okuda K, Kakizawa S, Sitsapesan R, Sato C, Takeshima H. Venturi E, et al. Among authors: pitt sj. Biochemistry. 2011 Apr 5;50(13):2623-32. doi: 10.1021/bi1019447. Epub 2011 Mar 7. Biochemistry. 2011. PMID: 21381722 Free PMC article.

3

TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.

Venturi E, Matyjaszkiewicz A, Pitt SJ, Tsaneva-Atanasova K, Nishi M, Yamazaki D, Takeshima H, Sitsapesan R. Venturi E, et al. Among authors: pitt sj. Pflugers Arch. 2013 Aug;465(8):1135-48. doi: 10.1007/s00424-013-1251-y. Epub 2013 Mar 7. Pflugers Arch. 2013. PMID: 23467973 Free PMC article.

4

FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation.

Venturi E, Galfré E, O'Brien F, Pitt SJ, Bellamy S, Sessions RB, Sitsapesan R. Venturi E, et al. Among authors: pitt sj. Biophys J. 2014 Feb 18;106(4):824-33. doi: 10.1016/j.bpj.2013.12.041. Biophys J. 2014. PMID: 24559985 Free PMC article.

5

Ca²+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca²+ regulation.

Carter S, Pitt SJ, Colyer J, Sitsapesan R. Carter S, et al. Among authors: pitt sj. J Membr Biol. 2011 Mar;240(1):21-33. doi: 10.1007/s00232-011-9339-9. Epub 2011 Jan 28. J Membr Biol. 2011. PMID: 21274522 Free PMC article.

6

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.

Galfré E, Pitt SJ, Venturi E, Sitsapesan M, Zaccai NR, Tsaneva-Atanasova K, O'Neill S, Sitsapesan R. Galfré E, et al. Among authors: pitt sj. PLoS One. 2012;7(2):e31956. doi: 10.1371/journal.pone.0031956. Epub 2012 Feb 21. PLoS One. 2012. PMID: 22363773 Free PMC article.

7

Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels.

Pitt SJ, Reilly-O'Donnell B, Sitsapesan R. Pitt SJ, et al. J Physiol. 2016 Aug 1;594(15):4171-9. doi: 10.1113/JP270936. Epub 2016 Mar 31. J Physiol. 2016. PMID: 26872338 Free PMC article. Review.

8

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.

Pitt SJ, Funnell TM, Sitsapesan M, Venturi E, Rietdorf K, Ruas M, Ganesan A, Gosain R, Churchill GC, Zhu MX, Parrington J, Galione A, Sitsapesan R. Pitt SJ, et al. J Biol Chem. 2010 Nov 5;285(45):35039-46. doi: 10.1074/jbc.M110.156927. Epub 2010 Aug 18. J Biol Chem. 2010. PMID: 20720007 Free PMC article.

9

Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.

Pitt SJ, Lam AK, Rietdorf K, Galione A, Sitsapesan R. Pitt SJ, et al. Sci Signal. 2014 May 20;7(326):ra46. doi: 10.1126/scisignal.2004854. Sci Signal. 2014. PMID: 24847115 Free PMC article.

10

Dysregulated Zn²⁺ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca²⁺ leakage.

Reilly-O'Donnell B, Robertson GB, Karumbi A, McIntyre C, Bal W, Nishi M, Takeshima H, Stewart AJ, Pitt SJ. Reilly-O'Donnell B, et al. Among authors: pitt sj. J Biol Chem. 2017 Aug 11;292(32):13361-13373. doi: 10.1074/jbc.M117.781708. Epub 2017 Jun 19. J Biol Chem. 2017. PMID: 28630041 Free PMC article.

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