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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS. Molnarfi N, et al. Among authors: bernard cc. J Exp Med. 2013 Dec 16;210(13):2921-37. doi: 10.1084/jem.20130699. Epub 2013 Dec 9. J Exp Med. 2013. PMID: 24323356 Free PMC article.
MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.
Varrin-Doyer M, Shetty A, Spencer CM, Schulze-Topphoff U, Weber MS, Bernard CC, Forsthuber T, Cree BA, Slavin AJ, Zamvil SS. Varrin-Doyer M, et al. Among authors: bernard cc. Neurol Neuroimmunol Neuroinflamm. 2014 Aug 14;1(2):e20. doi: 10.1212/NXI.0000000000000020. eCollection 2014 Aug. Neurol Neuroimmunol Neuroinflamm. 2014. PMID: 25340072 Free PMC article.
Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.
Shetty A, Gupta SG, Varrin-Doyer M, Weber MS, Prod'homme T, Molnarfi N, Ji N, Nelson PA, Patarroyo JC, Schulze-Topphoff U, Fogal SE, Forsthuber T, Sobel RA, Bernard CC, Slavin AJ, Zamvil SS. Shetty A, et al. Among authors: bernard cc. Neurol Neuroimmunol Neuroinflamm. 2014 Aug 14;1(2):e22. doi: 10.1212/NXI.0000000000000022. eCollection 2014 Aug. Neurol Neuroimmunol Neuroinflamm. 2014. PMID: 25340074 Free PMC article.
Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity.
Lehmann-Horn K, Kinzel S, Feldmann L, Radelfahr F, Hemmer B, Traffehn S, Bernard CC, Stadelmann C, Brück W, Weber MS. Lehmann-Horn K, et al. Among authors: bernard cc. Ann Clin Transl Neurol. 2014 Jul;1(7):490-6. doi: 10.1002/acn3.71. Epub 2014 Jul 3. Ann Clin Transl Neurol. 2014. PMID: 25356419 Free PMC article.
CNS accumulation of regulatory B cells is VLA-4-dependent.
Lehmann-Horn K, Sagan SA, Winger RC, Spencer CM, Bernard CC, Sobel RA, Zamvil SS. Lehmann-Horn K, et al. Among authors: bernard cc. Neurol Neuroimmunol Neuroinflamm. 2016 Mar 9;3(2):e212. doi: 10.1212/NXI.0000000000000212. eCollection 2016 Apr. Neurol Neuroimmunol Neuroinflamm. 2016. PMID: 27027096 Free PMC article.
Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen.
Kinzel S, Lehmann-Horn K, Torke S, Häusler D, Winkler A, Stadelmann C, Payne N, Feldmann L, Saiz A, Reindl M, Lalive PH, Bernard CC, Brück W, Weber MS. Kinzel S, et al. Among authors: bernard cc. Acta Neuropathol. 2016 Jul;132(1):43-58. doi: 10.1007/s00401-016-1559-8. Epub 2016 Mar 29. Acta Neuropathol. 2016. PMID: 27022743 Free PMC article.
192 results