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Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.
Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, Hyman BT, Gómez-Isla T. Coma M, et al. Among authors: saura ca. Neurobiol Dis. 2010 Jun;38(3):482-91. doi: 10.1016/j.nbd.2010.01.019. Epub 2010 Feb 10. Neurobiol Dis. 2010. PMID: 20149872 Free PMC article.
Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction.
Miñano-Molina AJ, España J, Martín E, Barneda-Zahonero B, Fadó R, Solé M, Trullás R, Saura CA, Rodríguez-Alvarez J. Miñano-Molina AJ, et al. Among authors: saura ca. J Biol Chem. 2011 Aug 5;286(31):27311-21. doi: 10.1074/jbc.M111.227504. Epub 2011 Jun 10. J Biol Chem. 2011. PMID: 21665950 Free PMC article.
66 results