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Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Berezovska O, et al. Among authors: lleo a. J Neurosci. 2005 Mar 16;25(11):3009-17. doi: 10.1523/JNEUROSCI.0364-05.2005. J Neurosci. 2005. PMID: 15772361 Free PMC article.
Moreover, by monitoring the relative distance between a PS1 loop epitope and the APP C terminus, we demonstrate that the FAD PS1 mutations are also associated with a consistent change in the configuration of the PS1-APP complex. ...We propose that the conformational …
Moreover, by monitoring the relative distance between a PS1 loop epitope and the APP C terminus, we demonstrate that the FAD PS1 muta …
Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Guardia-Laguarta C, et al. Among authors: lleo a. J Neurochem. 2009 Jul;110(1):220-30. doi: 10.1111/j.1471-4159.2009.06126.x. Epub 2009 Apr 27. J Neurochem. 2009. PMID: 19457132 Free PMC article.
Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.
Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Guix FX, et al. Among authors: lleo a. EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. EMBO Mol Med. 2012. PMID: 22488900 Free PMC article.
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.
Pera M, Alcolea D, Sánchez-Valle R, Guardia-Laguarta C, Colom-Cadena M, Badiola N, Suárez-Calvet M, Lladó A, Barrera-Ocampo AA, Sepulveda-Falla D, Blesa R, Molinuevo JL, Clarimón J, Ferrer I, Gelpi E, Lleó A. Pera M, et al. Among authors: lleo a. Acta Neuropathol. 2013 Feb;125(2):201-13. doi: 10.1007/s00401-012-1062-9. Epub 2012 Dec 6. Acta Neuropathol. 2013. PMID: 23224319 Free PMC article.
592 results