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Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Park MA, et al. Among authors: spiegel s. Cancer Res. 2010 Aug 1;70(15):6313-24. doi: 10.1158/0008-5472.CAN-10-0999. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631069 Free PMC article.
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Rosato RR, Maggio SC, Almenara JA, Payne SG, Atadja P, Spiegel S, Dent P, Grant S. Rosato RR, et al. Among authors: spiegel s. Mol Pharmacol. 2006 Jan;69(1):216-25. doi: 10.1124/mol.105.017145. Epub 2005 Sep 27. Mol Pharmacol. 2006. Retraction in: Mol Pharmacol. 2019 Apr;95(4):336. doi: 10.1124/mol.105.017145retraction PMID: 16189296 Retracted.
498 results