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SGLT2 mediates glucose reabsorption in the early proximal tubule.
Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. Vallon V, et al. Among authors: koepsell h. J Am Soc Nephrol. 2011 Jan;22(1):104-12. doi: 10.1681/ASN.2010030246. Epub 2010 Jul 8. J Am Soc Nephrol. 2011. PMID: 20616166 Free PMC article.
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.
Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, Parker HE, Gribble FM, Reimann F, Lang F, Wiese S, Sabolic I, Sendtner M, Koepsell H. Gorboulev V, et al. Among authors: koepsell h. Diabetes. 2012 Jan;61(1):187-96. doi: 10.2337/db11-1029. Epub 2011 Nov 28. Diabetes. 2012. PMID: 22124465 Free PMC article.
Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences.
Sabolic I, Vrhovac I, Eror DB, Gerasimova M, Rose M, Breljak D, Ljubojevic M, Brzica H, Sebastiani A, Thal SC, Sauvant C, Kipp H, Vallon V, Koepsell H. Sabolic I, et al. Among authors: koepsell h. Am J Physiol Cell Physiol. 2012 Apr 15;302(8):C1174-88. doi: 10.1152/ajpcell.00450.2011. Epub 2012 Jan 18. Am J Physiol Cell Physiol. 2012. PMID: 22262063 Free PMC article.
Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus.
Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Vallon V, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F156-67. doi: 10.1152/ajprenal.00409.2012. Epub 2012 Nov 14. Am J Physiol Renal Physiol. 2013. PMID: 23152292 Free PMC article.
SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.
Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T. Vallon V, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2014 Jan;306(2):F194-204. doi: 10.1152/ajprenal.00520.2013. Epub 2013 Nov 13. Am J Physiol Renal Physiol. 2014. PMID: 24226524 Free PMC article.
Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice.
Gallo LA, Ward MS, Fotheringham AK, Zhuang A, Borg DJ, Flemming NB, Harvie BM, Kinneally TL, Yeh SM, McCarthy DA, Koepsell H, Vallon V, Pollock C, Panchapakesan U, Forbes JM. Gallo LA, et al. Among authors: koepsell h. Sci Rep. 2016 May 26;6:26428. doi: 10.1038/srep26428. Sci Rep. 2016. PMID: 27226136 Free PMC article.
246 results