Mestan J - Search Results

1

A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

Choi HG, Ren P, Adrian F, Sun F, Lee HS, Wang X, Ding Q, Zhang G, Xie Y, Zhang J, Liu Y, Tuntland T, Warmuth M, Manley PW, Mestan J, Gray NS, Sim T. Choi HG, et al. Among authors: mestan j. J Med Chem. 2010 Aug 12;53(15):5439-48. doi: 10.1021/jm901808w. J Med Chem. 2010. PMID: 20604564 Free PMC article.

2

Allosteric inhibitors of Bcr-abl-dependent cell proliferation.

Adrián FJ, Ding Q, Sim T, Velentza A, Sloan C, Liu Y, Zhang G, Hur W, Ding S, Manley P, Mestan J, Fabbro D, Gray NS. Adrián FJ, et al. Among authors: mestan j. Nat Chem Biol. 2006 Feb;2(2):95-102. doi: 10.1038/nchembio760. Epub 2006 Jan 15. Nat Chem Biol. 2006. PMID: 16415863

3

Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study.

Ray A, Cowan-Jacob SW, Manley PW, Mestan J, Griffin JD. Ray A, et al. Among authors: mestan j. Blood. 2007 Jun 1;109(11):5011-5. doi: 10.1182/blood-2006-01-015347. Epub 2007 Feb 15. Blood. 2007. PMID: 17303698 Free article.

4

Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases.

Manley PW, Breitenstein W, Brüggen J, Cowan-Jacob SW, Furet P, Mestan J, Meyer T. Manley PW, et al. Among authors: mestan j. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5793-7. doi: 10.1016/j.bmcl.2004.09.042. Bioorg Med Chem Lett. 2004. PMID: 15501042

5

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

Weisberg E, Manley PW, Breitenstein W, Brüggen J, Cowan-Jacob SW, Ray A, Huntly B, Fabbro D, Fendrich G, Hall-Meyers E, Kung AL, Mestan J, Daley GQ, Callahan L, Catley L, Cavazza C, Azam M, Neuberg D, Wright RD, Gilliland DG, Griffin JD. Weisberg E, et al. Among authors: mestan j. Cancer Cell. 2005 Feb;7(2):129-41. doi: 10.1016/j.ccr.2005.01.007. Cancer Cell. 2005. PMID: 15710326 Free article.

6

Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia.

Manley PW, Cowan-Jacob SW, Mestan J. Manley PW, et al. Among authors: mestan j. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):3-13. doi: 10.1016/j.bbapap.2005.07.040. Epub 2005 Sep 8. Biochim Biophys Acta. 2005. PMID: 16172030 Review.

7

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.

Manley PW, Blasco F, Mestan J, Aichholz R. Manley PW, et al. Among authors: mestan j. Bioorg Med Chem. 2013 Jun 1;21(11):3231-9. doi: 10.1016/j.bmc.2013.03.038. Epub 2013 Apr 1. Bioorg Med Chem. 2013. PMID: 23611771

8

Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment.

Cowan-Jacob SW, Guez V, Fendrich G, Griffin JD, Fabbro D, Furet P, Liebetanz J, Mestan J, Manley PW. Cowan-Jacob SW, et al. Among authors: mestan j. Mini Rev Med Chem. 2004 Mar;4(3):285-99. doi: 10.2174/1389557043487321. Mini Rev Med Chem. 2004. PMID: 15032675 Review.

9

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants.

O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J, Cowan-Jacob SW, Lee FY, Heinrich MC, Deininger MW, Druker BJ. O'Hare T, et al. Among authors: mestan j. Cancer Res. 2005 Jun 1;65(11):4500-5. doi: 10.1158/0008-5472.CAN-05-0259. Cancer Res. 2005. PMID: 15930265

10

AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia.

Golemovic M, Verstovsek S, Giles F, Cortes J, Manshouri T, Manley PW, Mestan J, Dugan M, Alland L, Griffin JD, Arlinghaus RB, Sun T, Kantarjian H, Beran M. Golemovic M, et al. Among authors: mestan j. Clin Cancer Res. 2005 Jul 1;11(13):4941-7. doi: 10.1158/1078-0432.CCR-04-2601. Clin Cancer Res. 2005. PMID: 16000593

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