Liu Y - Search Results

1

A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

Choi HG, Ren P, Adrian F, Sun F, Lee HS, Wang X, Ding Q, Zhang G, Xie Y, Zhang J, Liu Y, Tuntland T, Warmuth M, Manley PW, Mestan J, Gray NS, Sim T. Choi HG, et al. Among authors: liu y. J Med Chem. 2010 Aug 12;53(15):5439-48. doi: 10.1021/jm901808w. J Med Chem. 2010. PMID: 20604564 Free PMC article.

2

SRC family kinases: potential targets for the treatment of human cancer and leukemia.

Warmuth M, Damoiseaux R, Liu Y, Fabbro D, Gray N. Warmuth M, et al. Among authors: liu y. Curr Pharm Des. 2003;9(25):2043-59. doi: 10.2174/1381612033454126. Curr Pharm Des. 2003. PMID: 14529415 Review.

3

Synthesis and target identification of hymenialdisine analogs.

Wan Y, Hur W, Cho CY, Liu Y, Adrian FJ, Lozach O, Bach S, Mayer T, Fabbro D, Meijer L, Gray NS. Wan Y, et al. Among authors: liu y. Chem Biol. 2004 Feb;11(2):247-59. doi: 10.1016/j.chembiol.2004.01.015. Chem Biol. 2004. PMID: 15123286

4

Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.

Han S, Zhou V, Pan S, Liu Y, Hornsby M, McMullan D, Klock HE, Haugen J, Lesley SA, Gray N, Caldwell J, Gu XJ. Han S, et al. Among authors: liu y. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73. doi: 10.1016/j.bmcl.2005.08.097. Epub 2005 Sep 30. Bioorg Med Chem Lett. 2005. PMID: 16199156

5

Allosteric inhibitors of Bcr-abl-dependent cell proliferation.

Adrián FJ, Ding Q, Sim T, Velentza A, Sloan C, Liu Y, Zhang G, Hur W, Ding S, Manley P, Mestan J, Fabbro D, Gray NS. Adrián FJ, et al. Among authors: liu y. Nat Chem Biol. 2006 Feb;2(2):95-102. doi: 10.1038/nchembio760. Epub 2006 Jan 15. Nat Chem Biol. 2006. PMID: 16415863

6

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.

Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Sim T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Ohmori O, Caldwell J, Gray N, He Y. Choi HS, et al. Among authors: liu y. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2173-6. doi: 10.1016/j.bmcl.2006.01.053. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458503

7

Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library.

Zhang Q, Liu Y, Gao F, Ding Q, Cho C, Hur W, Jin Y, Uno T, Joazeiro CA, Gray N. Zhang Q, et al. Among authors: liu y. J Am Chem Soc. 2006 Feb 22;128(7):2182-3. doi: 10.1021/ja0567485. J Am Chem Soc. 2006. PMID: 16478150

8

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.

Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Che J, Lee CC, Caldwell J, Kanazawa T, Umemura I, Matsuura N, Ohmori O, Honda T, Gray N, He Y. Choi HS, et al. Among authors: liu y. Bioorg Med Chem Lett. 2006 May 15;16(10):2689-92. doi: 10.1016/j.bmcl.2006.02.032. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16524731

9

Rational design of inhibitors that bind to inactive kinase conformations.

Liu Y, Gray NS. Liu Y, et al. Nat Chem Biol. 2006 Jul;2(7):358-64. doi: 10.1038/nchembio799. Nat Chem Biol. 2006. PMID: 16783341

10

A general strategy for creating "inactive-conformation" abl inhibitors.

Okram B, Nagle A, Adrián FJ, Lee C, Ren P, Wang X, Sim T, Xie Y, Wang X, Xia G, Spraggon G, Warmuth M, Liu Y, Gray NS. Okram B, et al. Among authors: liu y. Chem Biol. 2006 Jul;13(7):779-86. doi: 10.1016/j.chembiol.2006.05.015. Chem Biol. 2006. PMID: 16873026

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