Lehr M - Search Results

1

1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.

Drews A, Bovens S, Roebrock K, Sunderkötter C, Reinhardt D, Schäfers M, van der Velde A, Schulze Elfringhoff A, Fabian J, Lehr M. Drews A, et al. Among authors: lehr m. J Med Chem. 2010 Jul 22;53(14):5165-78. doi: 10.1021/jm1001088. J Med Chem. 2010. PMID: 20583844

2

Synthesis, biological evaluation, and structure-activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2.

Lehr M. Lehr M. J Med Chem. 1997 Aug 15;40(17):2694-705. doi: 10.1021/jm960863w. J Med Chem. 1997. PMID: 9276015

3

Structure-activity relationships of (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: variation of the substituents in positions 1, 3, and 5.

Lehr M. Lehr M. J Med Chem. 1997 Oct 10;40(21):3381-92. doi: 10.1021/jm970045j. J Med Chem. 1997. PMID: 9341913

4

Comparison of the inhibition of the cytosolic phospholipase A2-mediated arachidonic acid release by several indole-2-carboxylic acids and 3-(pyrrol-2-yl)propionic acids in bovine and in human platelets.

Lehr M, Elfringhoff AS. Lehr M, et al. Arch Pharm (Weinheim). 2000 Sep;333(9):312-4. doi: 10.1002/1521-4184(20009)333:9<312::aid-ardp312>3.0.co;2-y. Arch Pharm (Weinheim). 2000. PMID: 11039188

5

Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2).

Lehr M, Klimt M, Elfringhoff AS. Lehr M, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2569-72. doi: 10.1016/s0960-894x(01)00472-3. Bioorg Med Chem Lett. 2001. PMID: 11551751

6

Structure-activity relationship studies of 1-substituted 3-dodecanoylindole-2-carboxylic acids as inhibitors of cytosolic phospholipase A2-mediated arachidonic acid release in intact platelets.

Griessbach K, Klimt M, Schulze Elfringhoff A, Lehr M. Griessbach K, et al. Among authors: lehr m. Arch Pharm (Weinheim). 2002;335(11-12):547-55. doi: 10.1002/ardp.200290008. Arch Pharm (Weinheim). 2002. PMID: 12596219

7

HPLC assay with UV spectrometric detection for the evaluation of inhibitors of cytosolic phospholipase A2.

Schmitt M, Lehr M. Schmitt M, et al. Among authors: lehr m. J Pharm Biomed Anal. 2004 Apr 1;35(1):135-42. doi: 10.1016/j.jpba.2003.12.021. J Pharm Biomed Anal. 2004. PMID: 15030888

8

Structure-activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2alpha-mediated arachidonic acid release in intact platelets: variation of the keto moiety.

Ghasemi A, Elfringhoff AS, Lehr M. Ghasemi A, et al. Among authors: lehr m. J Enzyme Inhib Med Chem. 2005 Oct;20(5):429-37. doi: 10.1080/14756360500228338. J Enzyme Inhib Med Chem. 2005. PMID: 16335050 Free article.

9

Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.

Ludwig J, Bovens S, Brauch C, Elfringhoff AS, Lehr M. Ludwig J, et al. Among authors: lehr m. J Med Chem. 2006 Apr 20;49(8):2611-20. doi: 10.1021/jm051243a. J Med Chem. 2006. PMID: 16610804

10

Normal-phase HPLC and HPLC-MS studies of the metabolism of a cytosolic phospholipase A(2)alpha inhibitor with activated ketone group by rat liver microsomes.

Fabian J, Lehr M. Fabian J, et al. Among authors: lehr m. J Pharm Biomed Anal. 2007 Jan 17;43(2):601-5. doi: 10.1016/j.jpba.2006.07.017. Epub 2006 Aug 23. J Pharm Biomed Anal. 2007. PMID: 16930912

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