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IFN-gamma primes intact human coronary arteries and cultured coronary smooth muscle cells to double-stranded RNA- and self-RNA-induced inflammatory responses by upregulating TLR3 and melanoma differentiation-associated gene 5.
Ahmad U, Ali R, Lebastchi AH, Qin L, Lo SF, Yakimov AO, Khan SF, Choy JC, Geirsson A, Pober JS, Tellides G. Ahmad U, et al. Among authors: yakimov ao. J Immunol. 2010 Jul 15;185(2):1283-94. doi: 10.4049/jimmunol.0902283. Epub 2010 Jun 18. J Immunol. 2010. PMID: 20562257 Free PMC article.
Heparin displaces interferon-gamma-inducible chemokines (IP-10, I-TAC, and Mig) sequestered in the vasculature and inhibits the transendothelial migration and arterial recruitment of T cells.
Ranjbaran H, Wang Y, Manes TD, Yakimov AO, Akhtar S, Kluger MS, Pober JS, Tellides G. Ranjbaran H, et al. Among authors: yakimov ao. Circulation. 2006 Sep 19;114(12):1293-300. doi: 10.1161/CIRCULATIONAHA.106.631457. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940188