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Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.
Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Tanaka K, et al. Among authors: takimoto t. J Immunol. 2008 Mar 15;180(6):3746-56. doi: 10.4049/jimmunol.180.6.3746. J Immunol. 2008. PMID: 18322180
Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway.
Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A. Wakabayashi Y, et al. Among authors: takimoto t. J Biol Chem. 2011 Oct 14;286(41):35456-35465. doi: 10.1074/jbc.M111.236794. Epub 2011 Aug 23. J Biol Chem. 2011. PMID: 21862595 Free PMC article.
428 results